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Key value for chemical safety assessment

Additional information

The key study (Thompson, 2002) was conducted according to GLP and standardised guidelines with a sufficient level of detail to assess the quality of the study. Salmonella typhimurium (strains; TA100, TA1537, TA 1535 and TA98) and Escherichia coli (strain: WP2uvrA) were exposed to concentration of the test material ranging from 15 – 5000 µg/plate in the presence and absence of metabolic activator S9-mix. The test material gave a negative response with none of the assays showing a significant change in revertant colony numbers and is said to be non-mutagenic. The study was performed to a good standard and was assigned a reliability score of 1 using the principles for assessing data quality as set out in Klimisch (1997).

Short description of key information:
The genetic toxicity of 1-bromohexadecane was determined to be negative according to a study performed in line with standardised guidelines OECD 471, EU Method B13/14 and EPA OPPTS 870.5100 harmonised guidelines.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The genetic toxicity study indicates that the test material has no effect which requires classification. Therefore the material does not require classification under Regulation EC 1272/2008.