1,1'-(dodecylimino)dipropan-2-ol + 1,1'-(tetradecylimino)dipropan-2-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: scientifically acceptable and well documented

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Three groups of 5 male and 5 female Wister rats (avarage weight 173-177 g) each reveived per gavage 2000, 3100 or 5000 mg/kg bw Vorprodukt Katalysator WAZ 5596 B. The animals were observed for mortality, weight and clinical signs through day 14. A gross pathological examination was performed on animals which died during the observation period or were killed after termination of the study.

GLP compliance:

yes

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

1,1'-(dodecylimino)dipropan-2-ol

EC Number:

216-276-2

EC Name:

1,1'-(dodecylimino)dipropan-2-ol

Cas Number:

1541-66-8

Molecular formula:

C18H39NO2

IUPAC Name:

1,1'-(dodecylimino)dipropan-2-ol

Details on test material:

Vorprodukt Katalysator WAZ 5596 B, brown liquid

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

polyethylene glycol

Remarks:

Lutrol

Doses:

2000, 3100 or 5000 mg/kg bw

No. of animals per sex per dose:

5 per sex/dose

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Sex:

female

Dose descriptor:

LD50

Effect level:

ca. 2 500 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male

Dose descriptor:

LD50

Effect level:

>= 3 100 - <= 5 000 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

A single dose of 3100 and 5000 mg/kg bw Vorprodukt Katalysator WAZ 5596 B caused to following signs of intoxication: sedation, cyanosis, disordered breathing and a reduction of general condition rough fur, and bloody eye lids. An increased diuresis was observed on male rats and female rats dosed with 3100 or 2000 mg/kg bw, respectively. Staggered gait and bloody snouts were obvious on males with 3100 and 5000 mg/kg bw and on females with 2000 to 5000 mg/kg bw. Sedation and prone position was seen at one male and several female rats at doses of 5000 mg/kg bw or 3100 and 5000 mg/kg bw, respectively.

Gasping had three female rats. One male and one female each dosed with 5000 mg/kg bw had signs of paralysis on the hind legs. Weight reduction was observed on 3 females dosed with 2000 mg/kg bw and 1 male rats dosed with 3100 mg/kg bw during the first observation week.

Additional, with doses of 200 to 400 µl/kg bw a weight reduction was observed.

Symptoms were evident 1 hour after application and continued until the last day of the examination period. Deads occured after 3 hours until day 3.

Applicant's summary and conclusion

Executive summary:

Three groups of 5 male and 5 female Wister rats (avarage weight 173-177 g) each reveived per gavage 2000, 3100 or 5000 mg/kg bw Vorprodukt Katalysator WAZ 5596 B. The animals were observed for mortality, weight and clinical signs through day 14. A gross pathological examination was performed on animals which died during the observation period or were killed after termination of the study. The approximative LD50 was 3100 to 5000 mg/kg bw for male rats and 2500 mg/kg bw for female rats.