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Registration Dossier
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EC number: 239-743-2 | CAS number: 15667-63-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1-cyanoallyl acetate
- EC Number:
- 239-743-2
- EC Name:
- 1-cyanoallyl acetate
- Cas Number:
- 15667-63-7
- Molecular formula:
- C6H7NO2
- IUPAC Name:
- 1-cyanoprop-2-en-1-yl acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-23
- Humidity (%): 50-60
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: tragacanth (0.5%)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 11.2; 13.6; 15; 16.5; 18.1 mg/L
- Amount of vehicle (if gavage): 2.15 ml/kg
- Justification for choice of vehicle: test substance not soluble in water
- Doses:
- 0.024-0.038 mL/kg corresponding to 24.1-39.0 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: no - Statistics:
- Probit analysis
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 33.7 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 31.1 - 36.5
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 31.6 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 28.6 - 34.8
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 32.7 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 30.8 - 34.4
- Mortality:
- Mortality (if any) was observed within 30 min after administration
males: 24.5 mg/kg bw: 0/5
29.6 mg/kg bw: 1/5
35.7 mg/kg bw: 4/5
38.8 mg/kg bw: 5/5
females: 29.6 mg/kg bw: 0/5
32.6 mg/kg bw: 2/5
35.7 mg/kg bw: 3/5
38.8 mg/kg bw: 5/5 - Clinical signs:
- other: Clonic (and tonic) convulsions, tremor, decrease of muscle tone, general loss of reflexes, dyspnea, redness of the skin in females. Symptoms appeared 2 min after administration and persisited in surviving animals 1 to 6 h.
- Gross pathology:
- Only red decoloration of mucosa of the gastrointestinal tracts observed in some animals. No other changes were found.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Remarks:
- Migrated information
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