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Long-term toxicity to fish

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Description of key information

NOEC (33d) = 101 µg a.i./L (Pimephales promelas)

Key value for chemical safety assessment

Additional information

No information about the chronic toxicity of KDDC (CAS No. 128-03-0) to fish species is available. Therefore, conclusions concerning this endpoint had to be drawn based on toxicity data from an analogue substance. The chronic toxicity of Ziram (CAS No. 137-30-4) to Pimephales promelas was investigated by Palmer et al. (2006). This test was performed according to OECD Guideline No. 210 and EPA OPPTS 850.1400, Fish, Early-Life Stage Toxicity Test (1992, 1996), under GLP conditions. Fish embryos were exposed for 33 days to the test substance within a flow-through water regime. Hatching success was significantly reduced at the highest tested concentration (750 µg a.i./L) whereas growth of the surviving larvae at the end of the test did not differ between treatment groups and controls. Larval mortality reached 100% at concentrations of 393 and 750 µg a.i./L and was significantly reduced at the 195 µg a.i./L concentration. The NOEC was determined to be 101 µg a.i./L.