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Experimental data from tests investigating the toxicity of KDDC to terrestrial organisms were not conducted since studies from similar analogues are considered suitable for this purpose in accordance with the specifications listed in Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances and read across, on basis of structural similarity, physico-chemical properties, ecotoxicological profiles. There is no convincing evidence that any one of these chemicals might lie out of the overall profile of this analogue approach, respectively. Conclusions regarding this section were drawn based on studies performed on SDDC (sodium dimethyldithiocarbamate, CAS No. 128-04-1) and Ziram (zinc bis(dimethyldithiocarbamate), CAS No. 137-30-4). KDDC, SDDC and Ziram represent salts of dimethyl dithiocarbamic acid (DDC) that are capable of dissociating into the respective ions when exposed to water. The main differences between Ziram and KDDC/SDDC are the solubility in water and partition coefficient related to the rather covalent character of the zinc-sulphur bond with respect to the sodium-sulphur bond. The physico-chemical parameters of the three substances are listed in the table below.

Table 2. Physico-chemical parameters of KDDC, SDDC and Ziram





Molecular weight

159.3 g/mol

143.2 g/mol

305.8 g/mol

Melting point

Partial melting from 81.5 to 85.0°C followed by slow decomposition

Decomposition at
≥ 253°C

251.0 – 252.5°C
Colour change beginning at 238°C

Relative density at 20°C




Vapour pressure at 25°C


< 2×10–4Pa


Log Pow at 20°C

read across to SDDC

pH 5: = –3.2
pH 7: < –2.28
pH 9: < –2.33


pH range: 7.4-8.6[1]

Water solubility

read across to SDDC

37.4 - 40% (w/w)
pH 10.5

pH range: 7.2-7.41

*data are not presented within this dossier, but where subject to the respective REACh-registration of Ziram (CAS: 137-30-4, EC: 205-288-3)

An acute earthworm study is available for the analogue showing the highest resemblance to KDDC, i.e. SDDC. The remaining terrestrial endpoints were covered by data of Ziram. This approach can be considered as a worst-case scenario, since the comparison between SDDC and Ziram in a) aquatic toxicity tests (see technical dossier chapter 6.1) and b) for the terrestrial compartment (in acute earthworm studies),showed significantly lower effect concentrations for Ziram than those for SDDC (LC50(14d) = 140 mg a.i./kg soil (dw)* for Ziram and LC50(14d) = 787.6 mg a.i./kg soil (dw) for SDDC, respectively).

Based on the results from the studies performed on the analogue substances, KDDC may cause toxic effects to some terrestrial organisms (e.g. Eisenia fetida: NOEC of 4.053 mg a.i./kg dw soil).

The table below summarizes the effects of the analogue substances Ziram and SDDC to terrestrial organisms:

Table 4. Ecotoxicological data of SDDC and Ziram in the terrestrial compartment


Test duration

Effect value


Toxicity to soil macroorganisms except arthropods


LC50 = 787.6 mg a.i./kg soil d.w.


Toxicity to soil macroorganisms except arthropods


NOEC = 4.053 mg a.i./kg soil d.w.


Toxicity to terrestrial arthropods

48 h

LD50 > 100 µg per animal


Toxicity to terrestrial plants

21 d

NOEC = 9 kg/ha


Toxicity to soil microorganisms


NOEC = 40 kg/ha


Toxicity to birds

14 d

LD50 = 97 mg /kg bw


Toxicity to birds

5 d

LC50 = 5156 mg/kg diet


Toxicity to birds

20 wk

NOEC > 500 mg/kg diet