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Toxicity to soil macroorganisms except arthropods

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Description of key information

LC50 (14d) = 787.6 mg a.i./kg dw soil (Eisenia fetida)
NOEC (28d-mortality and reproduction) = 4 kg/ha = 4.053 mg a.i./kg dw soil (Eisenia fetida)

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Studies investigating the toxicity of KDDC (CAS No. 128-03-0) to soil macroorganisms are not available. Therefore, conclusions concerning this endpoint had to be drawn based on results from tests performed with analogue substances. The toxicity of SDDC (CAS No. 128-04-1) to soil macroorganisms was investigated by Moser (2007). This test was conducted according to OECD Guideline No. 207, Earthworm, Acute Toxicity Test (1984), under GLP conditions. Earthworms were exposed for 14 days to the test material in artificial soil at 20 ± 2°C, and lethal and sublethal effects were measured on days 7 and 14. Mortality was observed at all concentrations tested (5% at 10 mg a.i./kg dw soil to 55% at 1000 mg a.i./kg dw soil), resulting in a LC50 of 787.6 mg a.i./kg dw soil. Reductions in biomass (measured as weight) compared to control values were reported.


On the other hand, Wachter (1999) investigated the chronic effects of Ziram in earthworms. This study was performed according to the Draft ISO-Guideline 11268-2 (1993) and BBA Guideline, part VI, 2-2 (1995), under GLP conditions. Effects on survival and biomass were determined after 28 days of exposure, followed by an additional 28-days period where reproduction-related effects were assessed. No mortality was reported at any concentration tested. Adverse effects on reproduction (based on number of offsprings) were observed only at the highest concentration (NOEC 4.053 mg a.i./kg dw soil).