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EC number: 204-875-1 | CAS number: 128-03-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions concerning exposure duration
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPP 81-5 (Acute Dermal Irritation)
- Deviations:
- yes
- Remarks:
- Occlusive dressing; 24 h exposure time; 24 h-scoring time point is missing; post-exposure period was only 72 h; pH was 12.0
- GLP compliance:
- no
Test material
- Reference substance name:
- Potassium dimethyldithiocarbamate
- EC Number:
- 204-875-1
- EC Name:
- Potassium dimethyldithiocarbamate
- Cas Number:
- 128-03-0
- Molecular formula:
- C3H7NS2.K
- IUPAC Name:
- potassium (dimethylcarbamothioyl)sulfanide
- Details on test material:
- - Name of test material (as cited in study report): Busan 85
- Purity: no data
- Lot/batch No.: 1-6481
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Source: Dutchland Laboratories, Inc., Denver, PA, USA
Age: approx. 14 weeks
Weight: 2262-2597 g
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact, clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
-
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiping
- Time after start of exposure: 24 h
SCORING SYSTEM:
Erythema 0-4:
0: No erythema, 1: very slight erythema (barely perceptible), 2: well-defined erythema, 3 moderate to severe erythema, 4: severe erythema (beet redness) to slight eschar formation (injuries in depth)
Oedema 0-4:
0: No oedema, 1: very slight oedema (barely perceptible), 2: well-defined oedema (edges of area well-defined by definite raising), 3: moderate to severe oedema (raised approximately 1mm), 4: severe oedema (raised more than 1 mm extending beyond the area of exposure)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 48+72 h
- Score:
- 3.48
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 48+72 h
- Score:
- 2.88
- Max. score:
- 3.25
- Reversibility:
- not fully reversible within: 72 h
- Other effects:
- Blanching of the test area was seen in most animals at all scoring time points. In addition to this, subcutaneous haemorrhage and areas of necrosis in the test area occurred frequently.
Any other information on results incl. tables
Table A6.1.4S-1 Results of skin irritation study * |
||||||||||||
Observation time |
♂ |
♂ |
♂ |
♀ |
♀ |
♀ |
||||||
E |
Oe |
E |
Oe |
E |
Oe |
E |
Oe |
E |
Oe |
E |
Oe |
|
24 h** |
4.00 |
4.00 |
3.00 |
3.50 |
3.50 |
3.25 |
3.25 |
3.50 |
4.00 |
3.50 |
3.50 |
3.50 |
48 h |
4.00 |
2.50 |
–# |
– |
4.00 |
3.00 |
2.50 |
2.00 |
4.00 |
3.25 |
2.50 |
2.50 |
72 h |
4.00 |
2.25 |
– |
– |
4.00 |
2.75 |
2.50 |
2.00 |
4.00 |
3.00 |
2.50 |
2.25 |
Mean value |
4.00 |
2.92 |
– |
– |
3.83 |
3.00 |
2.75 |
2.50 |
4.00 |
3.25 |
2.83 |
2.75 |
* Values are means of both test sites ** Scoring time point: immediately after removal of test patch # Animal died on test |
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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