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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Reason / purpose:
reference to same study
Qualifier:
according to
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
yes
Remarks:
"slight modifications" is indicated
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Daphnia magna
Details on test organisms:
The daphnids were fed on 1 x 10^8 cells.L- 1 C. pyrenoidosa
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Reference substance (positive control):
not specified
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
2.9 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
mortality
Remarks on result:
other: (2.3 - 3.6)
Reported statistics and error estimates:
LC50 values and their 95% confidence intervals were calculated according to the Litchfield and Wilcoxon (1949) method.
Validity criteria fulfilled:
not specified
Conclusions:
The toxicity of tetramethylthiuram monosulphide to Daphnia magna was assessed according to the OECD 202 guideline with semi-static conditions. LC50 -48h was determined to be equal to 2.9 mg/L.
Executive summary:

The toxicity of tetramethylthiuram monosulphide to Daphnia magna was assessed according to the OECD 202 guideline with semi-static conditions. LC50 -48h was determined to be equal to 2.9 mg/L.

Description of key information

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
2.9 mg/L

Additional information

The acute toxicity of tetramethylthiuram monosulphide to Daphnia magna was assessed through several studies for which the followings EC50-48h were determined:

  • EC50-48h: 2.9 mg/L 
  • EC50-48h: 1.6 mg/L

The last data is mentioned in the HPV dossier Thiuram, but as the study belongs to another company, the tox data is considered as supporting data. Thus, the "key data" is EC50-48h = 2.9 mg/L