Registration Dossier
Registration Dossier
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EC number: 202-605-7 | CAS number: 97-74-5
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Activities of hepatic epoxide hydrolase and glutathione-S-transferase under influence of TMD, TMTM of dimethyl dithiocarbamate
- Author:
- Schreiner, E. & Freundt, K.J.
- Year:
- 1 985
- Bibliographic source:
- Toxicol.| Letters, 25, 147-152.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
- Type of method:
- other: in vitro and in vivo
Test material
- Reference substance name:
- Tetramethylthiuram monosulphide
- EC Number:
- 202-605-7
- EC Name:
- Tetramethylthiuram monosulphide
- Cas Number:
- 97-74-5
- Molecular formula:
- C6H12N2S3
- IUPAC Name:
- N,N-dimethyl[(dimethylcarbamothioyl)sulfanyl]carbothioamide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- one administration
- Frequency of treatment:
- one administration
- Post exposure period:
- 18-hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
up to 4.16 mmol/kg
Basis:
actual ingested
- No. of animals per sex per dose:
- no data
Examinations
- Examinations:
- The epoxide hydrolase activity, the glutathione-S-transferase activity in the cytosol and microsomes of the liver were measured.
- Positive control:
- no
Results and discussion
- Details on results:
- The epoxide hydrolase activity in the liver of adult female Wistar significantly increase 18 hours after the administration by gavage of TMTM (from 2.08 mmol/kg). The glutathione-S-transferase activity in the cytosol and microsomes of the liver was slightly enhanced after oral administration of TMTM (up to 4.16 mmol/kg). In vitro, TMTM significantly enhanced the hepatic activity of epoxide hydrolase prapared from adult rat.
Applicant's summary and conclusion
- Executive summary:
The epoxide hydrolase activity in the liver of adult female Wistar significantly increase 18 hours after the administration by gavage of TMTM (from 2.08 mmol/kg). The glutathione-S-transferase activity in the cytosol and microsomes of the liver was slightly enhanced after oral administration of TMTM (up to 4.16 mmol/kg). In vitro, TMTM significantly enhanced the hepatic activity of epoxide hydrolase prapared from adult rat.
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