Registration Dossier
Registration Dossier
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EC number: 202-605-7 | CAS number: 97-74-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Effet sur le systeme nerveux central du monosulfure de tetramethylthiurame comparaison avec le disulfirame.
- Author:
- Poitou, P. Marignac, B. et Gradiski, D.
- Year:
- 1 978
- Bibliographic source:
- J.Pharmacol., 9/1, 35-44.
Materials and methods
- Principles of method if other than guideline:
- Rats were treated with TMTM by ip.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Tetramethylthiuram monosulphide
- EC Number:
- 202-605-7
- EC Name:
- Tetramethylthiuram monosulphide
- Cas Number:
- 97-74-5
- Molecular formula:
- C6H12N2S3
- IUPAC Name:
- N,N-dimethyl[(dimethylcarbamothioyl)sulfanyl]carbothioamide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: EVIC CEBA
- Age at study initiation:
- Weight at study initiation: 200g
- Fasting period before study:
- Housing:
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Details on exposure:
- Administration volume = 5 ml/kg
- Doses:
- no data
- No. of animals per sex per dose:
- 10 animals /dose/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- ANOVA method
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 383 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 361 - 403
- Mortality:
- no data
- Clinical signs:
- hypothermia, hypoactivity
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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