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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980
Reference Type:
publication
Title:
Acute Toxicologic evaluation of Tetramethyl thiuram monosulfide
Author:
Bombard E., Löser E.
Year:
1996
Bibliographic source:
J.Am.Coll.Toxicol., Vol 15, Suppl.1

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
duration of observation after exposure : 8 days (and not 14 days).
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
tetramethylthiuram monosulfide
IUPAC Name:
tetramethylthiuram monosulfide
Constituent 2
Chemical structure
Reference substance name:
Tetramethylthiuram monosulphide
EC Number:
202-605-7
EC Name:
Tetramethylthiuram monosulphide
Cas Number:
97-74-5
Molecular formula:
C6H12N2S3
IUPAC Name:
N,N-dimethyl[(dimethylcarbamothioyl)sulfanyl]carbothioamide
Test material form:
solid: particulate/powder

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: W.Ostrop/Meerbusch
- Age at study initiation: no data
- Weight at study initiation: 2.9 kg
- Housing: individually
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7-14 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16-18 °C
- Humidity (%): 40%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
no
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
24 hours
Observation period:
24-48-72 hours, 8 days
Number of animals:
6 rabbits
Details on study design:
TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- % coverage: no details
- Type of wrap if used: Double layers of surgical gases

REMOVAL OF TEST SUBSTANCE: no

SCORING SYSTEM: as Draize score

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Remarks:
6 rabbits with intact skin
Time point:
24/48/72 h
Score:
0.1
Max. score:
4
Reversibility:
fully reversible within: 72 hr
Irritation parameter:
edema score
Basis:
mean
Remarks:
6 rabbits with intact skin
Time point:
24/48/72 h
Score:
0.83
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Irritant / corrosive response data:
A very sight erythema was observed in one rabbit at 24 hours after exposure to the test article.
Slight oedemas were observed in rabbit at 24 and 72 hours, and this effect was not reversible at 8 days.
Other effects:
no

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Remarks:
Not skin irritating
Conclusions:
According to this study, tetramethylthiuram monosulfide (TMTM) is slightly irritating for skin in rabbits but not classified based on CLP criteria.
Executive summary:

The potential of the test substance tetramethylthiuram monosulfide to induce skin irritation was evaluated in rabbits.

The test substance was applied for periods of 24 hours to a six New Zealand White rabbits. A single dose of 500 mg of the test substance with water was applied to the closely­clipped skin of one flank.

Slight cutaneous reactions (erythema and edema) were observed during the study: the mean erythema score for the 6 rabbits is 0.1/4 (mean 24/72h) and the mean oedema score is 0.83/4 (mean 24/72h). Erythema was fully reversible in 72 hours but oedema was not fully reversible in 8 days.

Under these experimental conditions, the test substance tetramethylthiuram monosulfide is slightly irritating when applied topically to rabbits but not classified based on CLP criteria.