Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2000
Report date:
2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
ethyl 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate
EC Number:
700-743-7
Cas Number:
161798-03-4
Molecular formula:
C18H21NO4S
IUPAC Name:
ethyl 2-[3-formyl-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylate

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
The animals were placed in an environmentally conditioned room with temperature within 22-25ºC, a relative humidity within 50-65%, rrom air ventilation of approximately 15times/hour, and lighting for 12 hours (7:00 - 19:00)

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 0.5% methylcelullose solution
Details on oral exposure:
The animals were daily observed to confirm whether or not they died, for 15 days after the administration, starting from the administration day.
Doses:
2000 mg/kg
No. of animals per sex per dose:
Ten rats of each sex were divided in two groups of 5 animals and given Isobutyl Derivative at 2000 mg/kg or the vehicle, 0.5% methylcelullose solution by gavage.
Spraque-Dawley rats (Crj: CD; SPF) of both sexes, 4 weeks old. These animals were quanrantined and acclimatized for 7 days.
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 2 000 mg/kg bw
Body weight:
All the animals showed normal increases in body weight throughtout the observation.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Migrated information
Conclusions:
From these results, it is considered that the 50% lethal dose (LD50) for Isobutyl Derivative by gavage in the rat is over 2000 mg/kg

Categories Display