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Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

Parent compound butyl chloroformate (CAS 592-34-7, rapidly hydrolyzing): No data available.

Hydrolysis product hydrogen chloride (HCL, CAS 7647 -01 -0): Acutely very toxic to algae (pH dependent).

Hydrolysis product butanol (CAS 71 -36 -3): With high probability acutely not harmful to algae.

Key value for chemical safety assessment

Additional information

Data for parent compound butyl chloroformate (CAS 592-34-7):

No data on the algal toxicity are available for butyl chloroformate (CAS 592-34-7).

However, as the substance rapidly hydrolyses in contact with water to butanol (CAS 71 -36 -3), hydrogen chloride (CAS 7647-01-0) and carbon dioxide (CAS 124-38-9). The assessment is, therefore, based on the available data of the hydrolysis products.

 

No data on algal toxicity of carbon dioxide (CAS 124-38-9) to aquatic invertebrates are available.

 

Data for Hydrolysis product - hydrogen chloride (HCL, CAS 7647-01-0):

For the hydrolysis product hydrogen chloride (HCL, CAS 7647-01-0) data from a growth inhibition test according to OECD 201 with the freshwater green algae P. subcapitata are available (OECD SIDS, 2002). In this study a 72-h ErC50 value of 0.492 mg/L (acid equivalent to pH 5.3) and a 72-h NOErC value of 0.097 mg/L (acid equivalent to pH 6) were determined.

 

Hydrolysis product – butanol (CAS 71-36-3):

For the hydrolysis product butanol (CAS 71-36-3) a number of results from algal toxicity studies are available. The key effect data are a 72-h ErC50 > 1000 mg/L and a 72-h NOErC of 180 mg/L as observed in a study with the freshwater species P. subcapitata. The test was conducted according to OECD guideline 201 and in compliance with GLP criteria and the test concentrations were analytically verified (MOE, Japan; 1996). In addition, several studies with freshwater algae species (D. subspicatus; P. subcapitata) are also available for CAS 71-36-3. According to these supporting data the lowest ErC50 was 225 mg/L and the lowest ErC10 was 134 mg/L, based on initially measured test concentrations (P. subcapitata; OECD 201; Wong et al. 1998, as cited in SIDS 2001).

 

Assessment:

There are no algal toxicity data available considering the parent compound butyl chloroformate (CAS 592-34-7).

The key study with the hydrolysis product butanol (CAS 71-36-3) comes from a test with Pseudokirchneriella subcapitata. The study was performed according to according to OECD guideline 201; based on growth rate, the 72-h ErC50 was determined to be > 1000 mg/L (nominal), indicating no harmful acute effects (MOE, Japan; 2002). The 72-h NOErC was 180 mg/L 

In a study according to OECD 201 (OECD SIDS, 2002),the hydrogen chloride (HCL, CAS 7647-01-0) showed to be acutely very toxic to algae due to the low pH: 72-h ErC50 = 0.492 mg/L (acid equivalent to pH 5.3); 72-h NOErC = 0.097 (acid equivalent to pH 6).

 

Summary of algal toxicity data:

Compound

Species

Results

Guideline

Reference

Hydrolysis product

(CAS 7647 -01-0)

P. subcapitata

72-h ErC50 = 0.492 mg/L;

72-h NOErC = 0.097 mg/L

 

(pH-dependent; acid equivalent)

 

OECD 201

OECD SIDS (2002)

Hydrolysis product

(CAS 71-36-3)

P. subcapitata

72-h ErC50 > 1000 mg/L;

72-h NOErC = 180 mg/L

OECD 201

MOE, Japan (1996)

Hydrolysis product

(CAS 71-36-3)

div.

ErC50 >200 mg/L;

ErC10 >100 mg/L

OECD 201

OECD SIDS (2001); (summary of div. test results)