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Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 October, 2013 to 18 November, 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Specific details on test material used for the study:
Test material: FAT 36034/W
Appearance: Pink powder
Water solubility:
3.26 mg/L
Temp.:
20 °C
Remarks on result:
other: pH not specified

Individual Results


Preliminary Visual Estimation of the Water Solubility


Table: Appearance of the test mixtures in the preliminary test


 




















Amount of the test item in mg



Total volume in ml



Appearance of mixture



10



10



Undissolved



50



Undissolved



 


The preliminary visual experiments showed that the water solubility of the test item is very low.


 


Flask Method


Table 2: Water solubility of the test item – experiments A to D









































Experiment



A



B



C



D(blank)



Amount of test item(mg)



500



500



500



---



Stirring time at 30°C (h)



24



48



72



72



Measured concentration (μg/l)



3079



3187



3257



n.d.


< 0.13



Water solubility (mg/l)



3.08



3.19



3.26



---



 


Average experiments A to C: 3.18 mg/l


 


Table: Standard addition for recheck:
















Standard



Measured concentration (mg/l)



% Recovery



Sample C + 1.31 µg test item



1.35



103.0



 


The recovery of 103.0 % indicates a sufficient accuracy of the analytical method.

Conclusions:
The water solubility of the test item at a temperature of 20 °C was determined to be 3.26 mg/L.
Executive summary:

The water solubility of FAT 36034/W was determined in a study conducted according to OECD Guideline 105 and EU Method A.15. Shake flask method was used for this purpose. Based on the findings of the study, the water solubility was determined to be 3.26 mg/L.

Description of key information

The water solubility of FAT 36034/W was determined in a study conducted according to OECD Guideline 105 and EU Method A.15. Shake flask method was used for this purpose. Based on the findings of the study, the water solubility was determined to be 3.26 mg/L.

Key value for chemical safety assessment

Water solubility:
3.26 mg/L
at the temperature of:
20 °C

Additional information