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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2005-07-26 - 2005-12-14
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study, GLP
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Type:
log Pow
Partition coefficient:
3.1
Temp.:
25 °C
Remarks on result:
other: pH: no data

Summary of the results of the HPLC measurements of the reference compounds and the test item.

Sample No.1)

tR1

[min]

tR2

[min]

tR

[min]

k’

log k’ (x)

Log Pow (y)

0

0.76

0.76

0.76

-

-

-

1

3.54

3.55

3.55

3.671

0.565

2.12)

2

6.06

6.08

6.07

6.987

0.844

2.62)

3

8.05

8.06

8.06

9.605

0.982

3.22)

4

14.86

14.86

14.86

18.553

1.268

3.62)

5

22.77

22.77

22.77

28.961

1.462

4.02)

6

57.99

57.92

57.96

75.263

1.877

4.13)

Test item

9.14

 

 

11.006

1.042

3.074)

Test item

 

9.14

 

11.026

1.042

3.074)

Mean value

 

 

 

 

 

3.1

1) For the names of the reference compounds see details on methods

2) Results from the OECD guideline for the testing of chemicals No. 117: "Partition Coefficient (noctanol/water), HPLC method".

3) Results from: M. Harnisch et al.: J. Chromatogr. 282, 315-333 (1983).

4) Interpolated from linearized function log Pow = f(log k' ) of the calibration data.

The log Pow-values of the test item fall within a range of ± 0.1 units, thus the test is satisfactory.

The linear regression of the log k' of the calibration substances against their log Pow has a correlation coefficient of r = 0,9503.

Conclusions:
In a valid guideline study acc. OECD 117 with the HPLC method the log Pow of Butydiglycol methacrylate was 3.1 at 25 °C.
Executive summary:

In a valid guideline study acc. OECD 117 with the HPLC method the log Pow of Butydiglycol methacrylate was 3.1 at 25 °C.

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Description of key information

In a valid guideline study acc. OECD 117 with the HPLC method the log Pow of Butydiglycol methacrylate was 3.1 at 25 °C.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.02
at the temperature of:
25 °C

Additional information

Two equivalent studies acc. OECD 117 are available with log Pow 3.1 and 2.93. The GLP study was used as key study. Mean value: 3.01