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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Description of key information

Calculated with the program KOWWIN v1.67 a logPow of 3.14 was recieved for p-tolyl isocyanate (Currenta 2011).
For the hydrolysis product of p-tolyl isocyanate (p-toluidine) an experimental logPow of 1.39 was reported by Hansch 1995.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.39

Additional information

Due to hydrolysis the calculated logPow of 3.14 is from theoretical interest only. For the assessment of p-tolyl isocyanate the experimental logPow of 1.39 for p-toluidine should be taken into account.

Isocyanates are known to rapidly hydrolyse under the formation of the corresponding amine as well as solid polyurea compounds *. However, the insoluble inert polyurea is not assumed to cause environmental hazards due to the reduced uptake of high molecular mass compounds, whereas the amine is assumed to be the ecotoxicological relevant species. Concluding, tests performed using the corresponding amine can equally be used to assess the ecotoxicological hazards of isocyanates assuming the complete transfer of the isocyanate into the corresponding amine while neglecting the formation of a certain fraction ecotoxicological not active polyurea compounds. An underestimation of environmental hazards is thus avoided supporting a conservative and thus protective hazard assessment. * Bayer Industry Services (2004). 4-chlorophenyl-isocyanate: Investigation on Stability in Aqueous Test Solutions. Project No: 200300181. Leverkusen, Germany. Bayer Industry Services (2003). Isopropylisocyante: Investigation on Stability in Aqueous Test Solutions. Project No: 200300095. Leverkusen, Germany.