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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary source

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1956
Report date:
1956

Materials and methods

Principles of method if other than guideline:
Six rats reveived intraperitoneally a single dose in the range of of 50 - 1600 mg/kg bw p-tolylisocyanate. The animals were observed for mortality, weight and clinical signs.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
p-tolyl isocyanate
EC Number:
210-743-4
EC Name:
p-tolyl isocyanate
Cas Number:
622-58-2
Molecular formula:
C8H7NO
IUPAC Name:
1-isocyanato-4-methylbenzene

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Doses:
50 - 1600 mg/kg bw
No. of animals per sex per dose:
6 rats (totally)
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
50 - 100 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

Symptoms: weekness, ataxia

Time of death: 2 hours - 1 day

Applicant's summary and conclusion

Executive summary:

Six rats reveived intraperitoneally a single dose in the range of of 50 - 1600 mg/kg bw p-tolylisocyanate. The animals were observed for mortality, weight and clinical signs. The animals showed to following symptoms: weekness, ataxia. Time of death: 2 hours-1 day.

LD50 = approx. 800-1600 mg/kg bw