Registration Dossier
Registration Dossier
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EC number: 210-743-4 | CAS number: 622-58-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
no data
Additional information
There are no reproductive or developmental toxicity studies of p-tolyl isocyanate available. Since inhaled p-tolyl isocyanate vapour will react primarily with lung tissue so that other systemic organ systems or tissues would be affected only at exposure concentrations that produce sufficient lung toxicity. But the propensity of p-tolyl isocyanate to cause lung effects consequently led to secondary effects such as hypoxia that could influence developmental endpoints. Therefore it is not expected to yield useful information from a reproductive or developmental toxicity study of p-tolyl isocyanate vapor inhalation. Thus reproductive toxicity cannot be excluded, but it seems to be unlikely at non irritant p-tolyl isocyanate exposure concentrations.
Short description of key information:
No reproduction studies for p-tolyl isocyanate are available.
Effects on developmental toxicity
Additional information
There are no reproductive or developmental toxicity studies of p-tolyl isocyanate available. Since inhaled p-tolyl isocyanate vapour will react primarily with lung tissue so that other systemic organ systems or tissues would be affected only at exposure concentrations that produce sufficient lung toxicity. But the propensity of p-tolyl isocyanate to cause lung effects consequently led to secondary effects such as hypoxia that could influence developmental endpoints. Therefore it is not expected to yield useful information from a reproductive or developmental toxicity study of p-tolyl isocyanate vapor inhalation. Thus reproductive toxicity cannot be excluded, but it seems to be unlikely at non irritant p-tolyl isocyanate exposure concentrations.
Toxicity to reproduction: other studies
Additional information
no data
Justification for classification or non-classification
no data
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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