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EC number: 203-892-1 | CAS number: 111-65-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles, acceptable for assessment.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality occurred in any test animal over the 14-day observation period.
- Clinical signs:
- other: Clinical observations noted one-hour post exposure in 8 of 10 animals included depression, salivation, wheezing, rough coat, and soft feces. Two female rats appeared normal throughout the study. All animals appeared normal from day 2 through termination
- Gross pathology:
- No abnormal gross pathology findings were noted in any of the animals upon necropsy.
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: other: GHS, EU, 2007
- Conclusions:
- Based on the study design the test substance, Isooctane, needs not to be classified.
- Executive summary:
This data is being read across from the source study that tested 2,2,4-trimethylpentane based on analogue read across.
Based on the study design the test substance, Isooctane, needs not to be classified.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Limit test with 5000 mg/kg versus 2000 mg/kg as per guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Limit test with 5000 mg/kg versus 2000 mg/kg as per guideline
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2,4-trimethylpentane
- EC Number:
- 208-759-1
- EC Name:
- 2,2,4-trimethylpentane
- Cas Number:
- 540-84-1
- Molecular formula:
- C8H18
- IUPAC Name:
- 2,2,4-trimethylpentane
- Reference substance name:
- 208-758-1
- IUPAC Name:
- 208-758-1
- Details on test material:
- - Name of test material (as cited in study report): Isooctane
- Analytical purity: 100% pure commercial product
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations daily; weighing on initiation and on days 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality occurred in any test animal over the 14-day observation period.
- Clinical signs:
- other: Clinical observations noted one-hour post exposure in 8 of 10 animals included depression, salivation, wheezing, rough coat, and soft feces. Two female rats appeared normal throughout the study. All animals appeared normal from day 2 through termination
- Gross pathology:
- No abnormal gross pathology findings were noted in any of the animals upon necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Remarks:
- Criteria used for interpretation of results: other: GHS, EU, 2007
- Conclusions:
- Based on the study design the test substance, Isooctane, needs not to be classified.
- Executive summary:
Based on the study design the test substance, Isooctane, needs not to be classified.
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