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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetradecyl chloroformate
EC Number:
260-330-8
EC Name:
Tetradecyl chloroformate
Cas Number:
56677-60-2
Molecular formula:
C15H29ClO2
IUPAC Name:
tetradecyl carbonochloridate
Details on test material:
- Name of test material (as cited in study report): Myristylchlorformiat
- Physical state: liquid
- Analytical purity: no data

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Firma Gaukler
- Weight at study initiation: 2.69 - 3.05 kg
- Housing: individually
- Diet: ca. 130 g per animal/day
- Water: ca. 250 ml per animal/day
- Acclimation period: at leat 8 days


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30 - 70 %
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: untreated eyes of the same animals
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
Duration of treatment / exposure:
single application
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
3
Details on study design:
REMOVAL OF TEST SUBSTANCE
none


SCORING SYSTEM: as described in OECD guideline 405


TOOL USED TO ASSESS SCORE: no data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
0
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24748/72 hours
Score:
0
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
1.78
Reversibility:
fully reversible within: 8 days
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
0.33
Reversibility:
fully reversible within: 48 hours

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Conclusions:
Tetradecyl chloroformate was found to be non irritating to the eyes.
Executive summary:

The mean scores were 0 for corneal opacity, 0 for iris lesions, 1.78 for redness of the conjunctivae (1.67 for 2/3 and 2 for 1/3 animals), and 0.33 for edema formation (0.33 for the individual rabbits). Thus, the test substance is considered to be non irritating to the eye according to EU and GHS criteria.