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Alcohols, lanolin, distn. residues (CAS No. 90622-40-5) exhibits a log Koc value of > 5 and is poorly water soluble (< 0.1 mg/L). The Guidance on information requirements and chemical safety assessment, Chapter R7.b (ECHA, 2012) states that once insoluble chemicals enter a standard STP, they will be extensively removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms. Nevertheless, once this contact takes place, these substances are expected to be removed from the water column to a significant degree by adsorption to sewage sludge (Guidance on information requirements and chemical safety assessment, Chapter R.7a, (ECHA, 2012). Thus, discharged concentrations of this substance (if at all) into the aqueous compartment are likely to be low.

Furthermore, Alcohols, lanolin, distn. residues (CAS No. 90622-40-5) contains approximately 30% cholesterol and significant fraction of structure-related substances. Cholesterol is widely distributed in animal organisms and may be eliminated from the body via faeces, urine and skin surface. Further, cholesterol may be metabolised to bile acids, steroid hormones and vitamin D3. Therefore, based on the available published literature there is abundant evidence that the main components of Alcohols, Ianolin, distn. residues (CAS No. 90622 -40 -5) such as cholesterol are readily metabolised in the organism. The fact that cholesterol is readily metabolised may, in the interim, provide preliminary justification that the bioaccumulation of cholesterol and/or lanolin alcohols can be considered insignificant.

Taking all these information into account, it can be concluded that bioaccumulation of Alcohols, lanolin, distn. residues is expected to be low.

Furthermore, for the suitable read-across substance Lanolin alcohols (CAS No. 8027-33-6) a test on metabolism of Lanolin alcohols is proposed in order to confirm that the lanolin alcohols are readily metabolized. The dossier of Alcohols, lanolin, distn. residues (CAS No. 90622-40-5) will be updated as soon as possible and the Chemical Safety Assessment according to Annex I of Regulation (EC) No 1907/2006 will be re-evaluated based on the outcome of the new studies. Meanwhile, pending the outcome of the test proposal, bioaccumulation of lanolin alcohols is not considered to be of immediate concern to aquatic organisms.