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Short-term toxicity to aquatic invertebrates

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Description of key information

No toxic effects up to the limit of water solubility (< 0.1 mg/L) for Daphnia magna (OECD 202)

Key value for chemical safety assessment

Additional information

As no valid study is available for assessing the acute toxicity to aqutaic invertebrates of Alcohols, lanolin, distn. residues (CAS No. 90622-40-5), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the structurally related substance Alcohols, lanolin (CAS 8027-33-6) was conducted. In this case, the read across is justified due to the structural and physico-chemical similarities, as well as comparable environmental fate/ecotoxicological and toxicological behavior for both substances. A detailed analogue approach justification is provided in the technical dossier chapter 6.1 and Section 13.

The study with Alcohols, lanolin (CAS 8027-33-6) was performed under static conditions according to GLP and OECD guideline 202 using Daphnia magna as test organism (Beiersdorf, 2001). In this limit test, no mortality was observed up to a concentration of 0.13 mg/L. Hence, the EC50 (96 h) is determined to be > 0.13 mg/L based on the nominal concentration.

Based on this result it can be concluded that no toxicological short-term effects on aquatic organisms are expected up to the limit of water solubility for of Alcohols, lanolin, distn. residues.

Due to structural and property similarities to the analogue substance, Alcohols, lanolin (CAS 8027-33-6), this result is also applicable to read across to Alcohols, lanolin, distn. residues (CAS No. 90622-40-5).