N-(5-chloro-2-methoxyphenyl)-2-[(2-methoxy-4-nitrophenyl)azo]-3-oxobutyramide

Nanomaterial dustiness

Administrative data

Endpoint:

nanomaterial dustiness

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2021

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2021

Report date:

2021

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EN 15051-2 (Workplace exposure. Measurement of the dustiness of bulk materials - Rotating drum method)

Deviations:

no

GLP compliance:

not specified

Type of method:

rotating cylinder

Sampling:

Sample amount: 15 g
The sample was divided in eight equal lots using a rotary riffler, this rotary riffler is especially designed to minimize the loss of any fine dust. One of these divided lots has been used for determining the bulk density and the moisture content.

Test material

Test material information

Constituent 1

Reference substance name:

N-(5-chloro-2-methoxyphenyl)-2-[(2-methoxy-4-nitrophenyl)azo]-3-oxobutyramide

EC Number:

240-131-2

EC Name:

N-(5-chloro-2-methoxyphenyl)-2-[(2-methoxy-4-nitrophenyl)azo]-3-oxobutyramide

Cas Number:

15993-42-7

Molecular formula:

C18H17ClN4O6

IUPAC Name:

N-(5-chloro-2-methoxyphenyl)-2-[(2-methoxy-4-nitrophenyl)diazenyl]-3-oxobutanamide

Test material form:

solid: particulate/powder

Data gathering

Instruments:

The health related dustiness investigations have been performed using the 15051 rotating drum dustiness tester according to the European standard.

Results and discussion

Dustiness index

Key result

Remarks on result:

other: Dustiness mass fractions determined

Any other information on results incl. tables

Summary of the dustiness data of sample 1115C01 Batch: 121116STB according to EN 15051-2, measured at a relative humidity of 49 %.

	Sample mass	Inhalable fraction		Thoracic fraction		Respirable fraction
	g	mg	mg kg-1	mg	mg kg-1	mg	mg kg-1
1st test	14.9849	498.96	33298	127.03	8477	13.48	900
2nd	14.8460	528.05	35569	120.74	8133	13.23	891
3rd	15.2207	508.60	33415	117.22	7701	12.69	834
Average			34094		8104		875
RSD %			3.7%		4.8%		4.1%
Classification			High		High		High

Moisture content: 0.55 m/m%.

Bulk density: 376 kg/m3

Sample 1115C01 has a clearly high dustiness potential for all three fractions with 34094 mg/kg for the inhalable fraction, 8104 mg/kg for the thoracic fraction and 875 mg/kg for the respirable fraction.

The average relative standard deviation (RSD) of the intra RSD is typically below 17 %. The relative standard deviations obtained for the independent measurements are all below 5 % and are thus within the range of RSD values typically found for this methodology, confirming adequate sampling.

 

Applicant's summary and conclusion

Conclusions:

Sample 1115C01 is classified as high for all 3 fractions (inhalable fraction, thoracic fraction and respirable fraction).

Executive summary:

The dustiness of Sample 1115C01 was determined by EN 15051-rotating drum (method 2).

Results are shown below:

	Sample mass	Inhalable fraction		Thoracic fraction		Respirable fraction
	g	mg	mg kg-1	mg	mg kg-1	mg	mg kg-1
1st test	14.9849	498.96	33298	127.03	8477	13.48	900
2nd	14.8460	528.05	35569	120.74	8133	13.23	891
3rd	15.2207	508.60	33415	117.22	7701	12.69	834
Average			34094		8104		875
RSD %			3.7%		4.8%		4.1%
Classification			High		High		High