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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary literature

Data source

Reference
Reference Type:
other: secondary source
Title:
A review of the environmental impact and toxic effects of the given test chemical
Author:
Hassen et al.
Year:
1991
Bibliographic source:
Environmental protection division BC Environment Victoria British columbia,Octomber 1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: No data
Principles of method if other than guideline:
The acute toxicity study was conducted to evaluate the toxic effects of the given test chemical in rats by the inhalation route.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzimidazole-2-thiol
EC Number:
209-502-6
EC Name:
Benzimidazole-2-thiol
Cas Number:
583-39-1
Molecular formula:
C7H6N2S
IUPAC Name:
1H-benzimidazole-2-thiol
Details on test material:
- Name of test material : 2-Mercaptobenzimidazole
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
not specified
Duration of exposure:
4 h
Concentrations:
1270 mg/m3
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 1 270 mg/m³ air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: non toxic by inhalation route
Mortality:
not specified
Clinical signs:
other: not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The LC50 value was considered to be >1270 mg/m3 when rats were treated with the given test chemical by inhalation route for 4 hours.
Executive summary:

Acute inhalation toxicity study was conducted by using the given test chemical in rats at the dose concentration of 1270 mg/m3 via inhalation route for 4 hours of exposure.  

Animals were observed for mortality. No mortality was observed at 1270 mg/m3 in treated animals.

Hence, the LC50 value was considered to be >1270 mg/m3 when rats were treated with the given test chemical by inhalation route for 4 hours.

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