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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

ErC50 (72 h)> 100 mg/l (nominal), ErC10 (72h) >100 mg/l (nominal). No effects occur in the range of water solubility and well above the water solubility.
    
    
    
    
    

no effects occur in the range of water solubility and well above the water solub

Key value for chemical safety assessment

EC50 for freshwater algae:
100 mg/L
EC10 or NOEC for freshwater algae:
100 mg/L

Additional information

No studies are available for the substance therefore data from studies on category member substances were used for the assessement of toxicity potential to algae. Read-across to the structurally related category members Didodecyl fumarate (CAS 2402 -58 -6, MW 453 g/mol), Ditetradecyl fumarate (CAS 10341-03-4, MW 509 g/mol) and 2-Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9, MW 621-733 g/mol) was conducted. 2-Butenedioic acid (E)-, di-C8-18-alkyl esters (CAS 68610-90-2) exhibits a molecular weight range of 340.5 - 621 g/mol.Thus, the read across is covered by interpolation for this substance. The read across is justified due to a) the structural similarity of the category members and b) similar physico-chemical properties resulting in a similar environmental fate and ecotoxicity profile. Due to the structural and physico-chemical property similarities with the tested category members Didodecyl fumarate (CAS 2402-58-6), Ditetradecyl fumarate (CAS 10341-03-4) and 2-Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9), this result is also applicable to read across to 2-Butenedioic acid (E)-, di-C8-18-alkyl esters (CAS 68610-90-2).

Further justification is given within the endpoint summary 6.1 and within the read-across justification section 13.

The studies with Didodecyl fumarate (CAS 2402-58-6), Ditetradecyl fumarate (CAS 10341-03-4) and -Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9) were conducted according to GLP Principles and OECD guideline 201 using Desmodesmus subspicatus as test organism (Falk, 2012a, b, c). For these limit tests a loading rate of 100 mg/l and a control was performed with six replicates per treatment. As the water solubility of the test substances were below the limit of quantification of the laboratory, no monitoring of test substance concentration was performed. Between the control and the test substance treatments no significant differences in algae growth were observed in all tests. Therefore, the ErC50/ErC10 (72 h) for growth rate are determined to be > 100 mg/l (nominal) for Didodecyl fumarate (CAS 2402-58-6), Ditetradecyl fumarate (CAS 10341-03-4) and -Butenedioic acid (E)-, di-C18-22-alkyl esters (CAS 68921-53-9), respectively.

The results of all three studies show distinctly, that no effects occur in the range of water solubility and well above the water solubility.