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Physical & Chemical properties

Partition coefficient

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Endpoint:
partition coefficient
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
supporting study
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Partition coefficient type:
other: standard fat - water
Details on results:
The calculated log partition coefficient standard fat/water (log Pfw) of the test substance is -3.91.
Conclusions:
Due to the very high solubility in water (12240 mg/L) and the low solubility in fat (<1.51 mg/kg standard fat) it can be concluded that the log Pow <3.

However, since the solubility T-1063FM in fat cannot be directly compared with its solubility in octanol, the latter will be determined in a separate study and the log Pow of T-1063FM will be calculated.
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 February - 24 June 2003
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
Official Journal of the European Communities L383A volume 35, 29 December 1992
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
not specified
Key result
Remarks on result:
other: The partition coefficient test cannot be performed for the test substance.
Conclusions:
The log partition coefficient n-octanol/water (log Pow) of the test substance could not be determined in this study.

Description of key information

The log partition coefficient n-octanol/water (log Pow) could not be determined (EU Method A.8). However, based on high water solubility and very low solubility in fat it is concluded that log Pow is < 3.

Key value for chemical safety assessment

Log Kow (Log Pow):
-1
at the temperature of:
20 °C

Additional information

The calculated log partition coefficient standard fat/water (log Pfw) of the test substance is -3.91.


Due to the high solubility in water (>10000 mg/L) and the low solubility in fat (<0.151 mg/100g standard fat) it can be concluded that the log Pow <3.


For the purpose of risk assessment, a logKow value of -1 is taken (minimum value which is within the boundaries of the EUSES model).