Registration Dossier
Registration Dossier
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EC number: 457-330-7 | CAS number: 66034-17-1
Long-term toxicity to fish
Administrative data
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- experimental study planned
- Justification for type of information:
- TESTING PROPOSAL ON VERTEBRATE ANIMALS
NON-CONFIDENTIAL NAME OF SUBSTANCE:
- T1063FM
CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION [please address all points below]:
- Available GLP studies: not available
- Available non-GLP studies: not available
- (Q)SAR: no reliable QSAR predictions available
- In vitro methods: no in vitro results available
- Weight of evidence: available data do not allow a weight of evidence approach.
- Grouping and read-across: no suitable data for analogous substances to the test substance are available.
- Substance-tailored exposure driven testing [if applicable]: not applicable
- Approaches in addition to above [if applicable]: not applicable
CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
- The Board of Appeal's decision (A-011-2018) from 4 May 2020 states that REACH Annex IX (section 9.1, column 2) does not allow registrants to omit information on long-term toxicity to fish under column 1. Furthermore, the decision overrides advice given in the ECHA Guidance. This means that as a consequence, information on aquatic toxicity described in ECHA’s Guidance on Information Requirements and Chemical Safety Assessment related to REACH Annex IX, section 9.1, Column 2 as a waiver for the information requirement under Column 1 is no longer valid.
FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- ECHA considers the fish early-life stage toxicity test using the OECD TG 210 as the most appropriate and suitable.
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test)
Test material
- Reference substance name:
- -
- EC Number:
- 457-330-7
- EC Name:
- -
- Cas Number:
- 66034-17-1
- Molecular formula:
- Hill formula: C4H10N2:H4O7P2 CAS formula: C4H10N2:H4O7P2
- IUPAC Name:
- (phosphonooxy)phosphonic acid; piperazine
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
