Registration Dossier
Registration Dossier
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EC number: 200-493-4 | CAS number: 60-93-5
Endpoint summary
Administrative data
Description of key information
Additional information
Stability:
Data on the stability of quinine dihydrochloride are only available for phototransformation. The calculated phototransformation of quinine dihydrochloride in air, calculated from the hydroxyl radical turn over rate is 164.1943 E-012 cm^3/molecule/s (14.186 µm^3/molecule/d). Therefore, we consider phototransformation in air to be negligible. These results are calculated using AOP v1.92, expecting, that phototransformation appears at a constant rate. The EPA recommends that empirical measures provide better results. However, empirical studies have not been done, so that we adapt the prediction.
Biodegradation:
The read across substance quinine base anhydrous was tested in a CO2 Evolution Test according to the OECD Guideline 301 B for 28 days (and 29 days after acidification) to determine whether the test substance is readily biodegradable. After a lag phase of 10 days, the degradation extent of the test item reached 86.3 % by the end of the test (mean of three replicates). The reference compound sodium benzoate reached the pass levels for ready biodegradability within 3 days. The degradation of the toxicity control after 14 days was 86.6%. Thus, quinine had no inhibitory effects to the inoculum according to the criterion of the guideline. The read across substance quinine base anhydrous reached the criteria for ready biodegradability (60% ThCO2) within the 10-day time window. Therefore, quinine base anhydrous can be considered to be readily biodegradable. Thus, we assumed that quinine dihydrochloride is also readily biodegradable.
Bioaccumulation:
The given BCF, BAF and Biotransformation half-life estimations from the models for quinine dihydrochloride show, that quinine dihydrochloride has a low accumulation potential. Nevertheless, the EPA recommends that EPI Suite is a screening-level tool and should not be used if acceptable measured values are available. However, empirical studies have not been done, so that we consider a BCF of 3.16 L/kg, BAF of 0.893 L/kg and Biotransformation half-life of 0.0106 days.
Transport and distribution:
The EPI Suite v.4.1. results show that, quinine dihydrochloride adsorbs to carbon and in the environment. The major amount is distributed to soil. The estimated Henrys law constant of quinine dihydrochloride is 5.48E-018 Pa-m3/mole.
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