Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Justification for classification or non-classification

It is considered that there is sufficient evidence to justify the non-classification of the registered substance for carcinogenicity on the

basis of:

1)    Negative findings in tests for gene mutation / mutagenicity.

2)    Evaluation using Derek Nexus, an accepted (Q)SAR tool designed for the qualitative prediction of the possible toxicity of

chemicals, a procedure in accordance with Annex XI of Regulation 1907/2006. In this, the substance triggered no alerts for

carcinogenicity, chromosome damage, genotoxicity and mutagenicity.

Additional information

The substance has been evaluated over a range of toxicological endpoints and species using Derek Nexus. No alerts for carcinogenicity, chromosome damage, genotoxicity and mutagenicity were triggered and the structure should be regarded as negative for the endpoints.This is supported by available genetic toxicity studies which include a bacterial reverse mutation assay (Ames test), chromosome aberration study in cultured human lymphocytes and a study for the induction of 5‑trifluorothymidine resistant mutants in mouse lymphoma L5178Y cells after in vitro treatment.