Lactonitrile

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study with acceptable restrictions (non-GLP)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1991

Report date:

1991

Materials and methods

Principles of method if other than guideline:

Method: other: 79/831 EWG, Annex V part C

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Lactonitrile

EC Number:

201-163-2

EC Name:

Lactonitrile

Cas Number:

78-97-7

Molecular formula:

C3H5NO

IUPAC Name:

2-hydroxypropanenitrile

Details on test material:

Milchsaeurenitril (Lactonitrile)
Purity: 88%
Impurities: 12% acetic acid, 0.1% hydrogen cyanide, 0.1% acetaldehyde

Sampling and analysis

Analytical monitoring:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

EC0

Effect conc.:

0.625 mg/L

Effect concentrations 2

Duration:

48 h

Dose descriptor:

EC100

Effect conc.:

10 mg/L

Effect concentrations 3

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

1.77 mg/L

Any other information on results incl. tables

RS-Freetext:
Time   /  EC0  /  EC50 (95% confidential limit) / EC100
-----------------------------------------------------------
  3 h  /   5   /   9.7 (8.50 - 10.98)           /  20
  6 h  /   5   /   7.3 (6.72 - 7.97)            /  20
 24 h  / 0.625 /   2.2 (1.84 - 2.57)            /  10
 48 h  / 0.625 /   1.8 (1.54 - 2.03)            /  10
-----------------------------------------------------------