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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptable restrictions (non-GLP)

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)
Version / remarks:
Cited as OECD Guide-line 202, part 2 (Daphnia sp., Reproduction Test)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Lactonitrile
EC Number:
201-163-2
EC Name:
Lactonitrile
Cas Number:
78-97-7
Molecular formula:
C3H5NO
IUPAC Name:
2-hydroxypropanenitrile
Details on test material:
2-Hydroxypropanenitrile
Purity: 92.3 %

Sampling and analysis

Analytical monitoring:
no

Test organisms

Test organisms (species):
Daphnia magna

Results and discussion

Effect concentrationsopen allclose all
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
0.67 mg/L
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
0.17 mg/L
Basis for effect:
reproduction
Duration:
21 d
Dose descriptor:
LOEC
Effect conc.:
0.56 mg/L

Any other information on results incl. tables

RS-Freetext:
Mortality
LC50 (24 h) = 4.8 mg/L (95% confidence level: 2.8-11 mg/L)
LC50 (48 h) = 2.5 mg/L (95% conifidence level: 1.6-4.8 mg/L)
LC50 (96 h) = 1.9 mg/L (95% confidence level: 1.3-3.1 mg/L)
LC50 (7 d) = 1.4 mg/L (95% confidence level: 0.96-2.1 mg/L)
LC50 (14 d) = 0.84mg/L (95% confidence level: 0.62-1.2 mg/L)
LC50 (21 d) = 0.71mg/L (95% confidence level: 0.52-0.98 mg/L)
NOEC =
LOEC =

Reproduction
EC50 (14 d) = 0.78mg/L (95% confidence level: 0.5-1.2 mg/L)
EC50 (21 d) = 0.67mg/L (95% confidence level: 0.49-0.93 mg/L)
NOEC = 0.17mg/L (p <0.05)
LOEC = 0.56mg/L (p <0.05)

Applicant's summary and conclusion