Lactonitrile

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study meets generally accepted scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1986

Materials and methods

Objective of study:

metabolism

Principles of method if other than guideline:

Method: other

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Automatically generated during migration to IUCLID 6, no data available

IUPAC Name:

Automatically generated during migration to IUCLID 6, no data available

Details on test material:

IUCLID4 Test substance: other TS

TS-Freetext:
Lactonitrile
Purity unknown

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parameters

Toxicokinetic parameters 1

Toxicokinetic parameters:

half-life 2nd:

Toxicokinetic parameters 2

Toxicokinetic parameters:

half-life 1st:

Toxicokinetic parameters 3

Toxicokinetic parameters:

half-life 3rd:

Any other information on results incl. tables

RS-Freetext:
Mortality in mice following Lactonitrile treatment (0.26 mmol/kg) with  inhibitors of ethanol metabolism or prostaglandin synthetase and  a-Trocopherol

Treatment                                  / mortality
-----------------------------------------------------------
Normal saline (1 ml/100 g)                 / 8/10
4-Methylpyrazole (125 mg/kg, ip)           / 0/10*
Aspirin in water (80 mg/kg, ip)            / 4/10
DMSO (5.5 g/kg, ip)                        / 2/10*
lndomethacin (2 mg/kg, ip)                 / 3/10*
Sodium salicylate in water (320 mg/kg, ip) / 9/10 a-Tocopherol (25 mg/kg  ip in corn oil 25 hr and 1 hr
before cyanohydrins)                       / 8/10
a-Tocopherol (25 mg/kg ip in corn oil 25 hr before and 
100 mg/kg 1 hr before cyanohydrins)        / 8/10
-----------------------------------------------------------
* = Significance level p < 0.05


Cyanide release from Lactonitrile by yeast alcohol dehydrogenase (ug  CN/ml)

Buffer                 / sub. conc. / + ADH     / -ADH
-----------------------------------------------------------
Glycine (0.5M, pH9)    / 1.97 mg/ml / 7.8 ± 0.9 / 5.3 ± 1.3
Glycine (0.5M, pH9)    / 0.98 mg/ml / 5.3 ± 1.1 / 4.2 ± 1.6
Glycine (0.5M, pH9)    / 0.49 mg/ml / 2.3 ± 1.2 / 0.3 ± 0.1
Glycine (0.5M, pH9)    / 0.20 mg/ml / 0.8 ± 0.7 / -
Glycine (0.5M, pH9)    / 0.10 mg/ml / 0.6 ± 0.5 / - 
Phosphate (0.0Mm, pH7) / 0.98 mg/ml / 1.6 ± 0.2 / 2.1 ± 0.5
-----------------------------------------------------------