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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study meets generally accepted scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
Method: other
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
IUCLID4 Test substance: other TS

TS-Freetext:
Lactonitrile
Purity unknown

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parametersopen allclose all
Toxicokinetic parameters:
half-life 2nd:
Toxicokinetic parameters:
half-life 1st:
Toxicokinetic parameters:
half-life 3rd:

Any other information on results incl. tables

RS-Freetext:
Mortality in mice following Lactonitrile treatment (0.26 mmol/kg) with inhibitors of ethanol metabolism or prostaglandin synthetase and a-Trocopherol

Treatment / mortality
-----------------------------------------------------------
Normal saline (1 ml/100 g) / 8/10
4-Methylpyrazole (125 mg/kg, ip) / 0/10*
Aspirin in water (80 mg/kg, ip) / 4/10
DMSO (5.5 g/kg, ip) / 2/10*
lndomethacin (2 mg/kg, ip) / 3/10*
Sodium salicylate in water (320 mg/kg, ip) / 9/10 a-Tocopherol (25 mg/kg ip in corn oil 25 hr and 1 hr
before cyanohydrins) / 8/10
a-Tocopherol (25 mg/kg ip in corn oil 25 hr before and
100 mg/kg 1 hr before cyanohydrins) / 8/10
-----------------------------------------------------------
* = Significance level p < 0.05


Cyanide release from Lactonitrile by yeast alcohol dehydrogenase (ug CN/ml)

Buffer / sub. conc. / + ADH / -ADH
-----------------------------------------------------------
Glycine (0.5M, pH9) / 1.97 mg/ml / 7.8 ± 0.9 / 5.3 ± 1.3
Glycine (0.5M, pH9) / 0.98 mg/ml / 5.3 ± 1.1 / 4.2 ± 1.6
Glycine (0.5M, pH9) / 0.49 mg/ml / 2.3 ± 1.2 / 0.3 ± 0.1
Glycine (0.5M, pH9) / 0.20 mg/ml / 0.8 ± 0.7 / -
Glycine (0.5M, pH9) / 0.10 mg/ml / 0.6 ± 0.5 / -
Phosphate (0.0Mm, pH7) / 0.98 mg/ml / 1.6 ± 0.2 / 2.1 ± 0.5
-----------------------------------------------------------

Applicant's summary and conclusion