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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

The substance is considered to be not bioaccumulative with a BCF of 7.43 (Log BCF 0.87) calculated by Catalogic  vs. 5.11.9.

Key value for chemical safety assessment

BCF (aquatic species):
7.43 L/kg ww

Additional information


In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.


According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.


For the assessment of Amines, tri-C8 -10 -alkyl (CAS 68814 -95 -9) (Q)SAR results were used for aquatic bioaccumulation.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.


Therefore, and for reasons of animal welfare, further experimental studies on aquatic bioaccumulation are not provided.


QSAR estimations reveal a Log Kow of 11.83. The value indicate a potential for bioaccumulation. In the following the assessment of the bioaccumulation potential of Amines, tri-C8-10-alkyl will be based on the estimated log Kow of 11.83. Subsequent estimations of the BCF were performed with three different models. The results are evaluated in a weight-of-evidence approach.

A BCF calculation using the CATALOGIC v.5.11.9 BCF base-line model vs.2.05 is available for Amines, tri-C8-10-alkyl (CAS: 68814-95-9). The BCF model calculates the BCF implicating the estimated log Kow value of 11.83. Furthermore, the influence of mitigating factors like ionization of the molecule, water solubility, size and metabolism are also considered by the model. Taking into account these mitigating factors the BCF is reduced to 7.43 (log BCF = 0.871).

For molecular size a cut-off value is discussed in the literature indicating a limited bioaccumulation potential. The PBT working group on hazardous substances discussed a maximum diameter of > 17.4 Å (Comber et al., 2006).The DiamMax-Average of the test item is determined to be 20.35 Å depending on its conformation.

EPISuite v4.1/BCFBAFv3.01: The BCF was estimated to be 14.6 L/kg based on the regression-based method and the BCF estimation based on Arnot-Gobas upper trophic predict a BCF of 193 L/kg. Metabolism in fish was predicted to produce 4 types of primary metabolites. A biotransformation half-life of 52 days was estimated for a fish of 10 g wet weight.


Furthermore, the Guidance on information requirements and chemical safety assessment Chap. R11 PBT Assessment indicates that substances with a modeled Log Kow of > 10 are assumed to have a limited bioaccumulation potential.



Based on the results from Catalogic , BCFBAF and the information given the Guidance on information requirements and chemical safety assessment Chap. R11 PBT Assessment , it is concluded that the substance is not significantly bioaccumulative and therefore does not require a classification with regard to bioaccumulation.