Registration Dossier
Registration Dossier
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EC number: 201-810-9 | CAS number: 88-21-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The growth inhibition concentration (IGC50) value of 2-aminobenzenesulphonic acid in microorganism (Tetrahymena pyriformis) in a 48 hr study on the basis of growth inhibition effect was estimated to be 219.2835 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 219.28 mg/L
Additional information
No. of studies were reviewed for toxicity to microorganisms from reliable sources having Klimisch rating 2 and 4.
The summary of the results are presented below
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Sources |
1. |
IGC50 |
219.2835 mg/L |
growth inhibition |
48 hrs. |
Tetrahymena pyriformis |
Predicted data from QSAR for target CAS:88-21-1 |
2. |
IGC50 |
606.07 mg/L |
growth inhibition |
46 hrs. |
Tetrahymena pyriformis |
Predicted data from Danish QSAR for target CAS:88-21-1 |
3. |
EC50 |
114 mg/L |
- |
5 min. |
Photobacterium phosphoreum |
Experimental data from water pollution research journal Canada for read across CAS: 121-57-3 |
4 |
IC50 |
533 mg/L |
- |
- |
Saccharomyces cerevisiae |
Experimental data from Methods & Findings in Experimental & Clinical Pharmacology for read across CAS: 121-57-3 |
Based on the studies summarized in the above table for the target substance 2-aminobenzenesulphonic acid and read across substance, the endpoint value was found to be EC50 = 114 mg/L in 5 min.; IGC50 = 219.2835 mg/L to 606.07 mg/L in 46 hrs. to 48 hrs. and IC50 =533 mg/L on the basis of growth inhibition effect.
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