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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Toxicokinetics study
Author:
Anonymous
Year:
1993
Bibliographic source:
Toxikologische Bewertung. Heidelberg, Berufsgenossenschaft der chemischen Industrie 252: 27 (1993)

Materials and methods

Objective of study:
absorption
distribution
excretion
metabolism
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
4-Aminobenzene sulfonic acid
IUPAC Name:
4-Aminobenzene sulfonic acid
Constituent 2
Chemical structure
Reference substance name:
Sulphanilic acid
EC Number:
204-482-5
EC Name:
Sulphanilic acid
Cas Number:
121-57-3
Molecular formula:
C6H7NO3S
IUPAC Name:
4-aminobenzenesulfonic acid
Details on test material:
- Name of test material (as cited in study report):4-Aminobenzene sulfonic acid
- Molecular formula (if other than submission substance):C6H7NO3S
- Molecular weight (if other than submission substance):173.19 g/mol
- Substance type:Organic
- Physical state:solid
- Impurities (identity and concentrations):NA
Radiolabelling:
no

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intratracheal
Vehicle:
not specified
Details on exposure:
An intratracheally-instilled solution of 4- aminobenzene sulfonic acid was administered to the rat
Duration and frequency of treatment / exposure:
24 hrs
Doses / concentrations
Remarks:
Doses / Concentrations:
Not specified
No. of animals per sex per dose / concentration:
Not specified
Control animals:
not specified

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
Absorption through the lungs appears to be possible; absorption of an intratracheally-instilled solution of 4- aminobenzene sulfonic acid has been detected in the rat. 4-Aminobenzene sulfonic acid can also be absorbed from the gastrointestinal tract.
Type:
distribution
Results:
Accumulation does not take place in mammals.
Type:
metabolism
Results:
N-acetyl metabolite
Type:
excretion
Results:
4-Aminobenzene sulfonic acid is excreted either unchanged or as the N-acetyl metabolite, in the urine and the feces in rats.Excretion after oral administration mainly occurs within 24 hr.

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
N-acetyl metabolite

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
4-Aminobenzene sulfonic acid can be absorbed from the gastrointestinal tract. Absorption through the lungs appears to be possible; absorption of an intratracheally-instilled solution of 4- aminobenzene sulfonic acid has been detected in the rat. Accumulation does not take place in mammals; excretion after oral administration mainly occurs within 24 hr. 4-Aminobenzene sulfonic acid is excreted either unchanged or as the N-acetyl metabolite, in the urine and the feces in rats
Executive summary:

4-Aminobenzene sulfonic acid can be absorbed from the gastrointestinal tract. Absorption through the lungs appears to be possible; absorption of an intratracheally-instilled solution of 4- aminobenzene sulfonic acid has been detected in the rat. Accumulation does not take place in mammals; excretion after oral administration mainly occurs within 24 hr. 4-Aminobenzene sulfonic acid is excreted either unchanged or as the N-acetyl metabolite, in the urine and the feces in rats.