C4-C10 branched and linear hydrocarbons (light) – Naphtha

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

This endpoint has been reviewed, assessed and accepted by UK-HSE as competent authority for the notification of a new substance [EC number: 481-730-0; Data from UK-Notification Dossier by Shell U.K. Limited in accordance with Directive 92/32/EEC (Articles 7/8/9/12) O.J.L 154, Volume 35, 5 June 1992; Notification Report 06-31-0125-00 from 1st Nov, 2006].

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: review

Title:

Unnamed

Year:

2006

Materials and methods

Test guideline

Qualifier:

no guideline required

Principles of method if other than guideline:

The toxicity of the representative chemical components of the substance to fish have been calculated in accordance with the methods described by Peter Fisk Associates (2006) using QSARs for non-polar narcotics. The QSARs take the form of a generic equation:
log(LC50, EC50 or NOEC) = a log(Kow) + b
where a and b are constants equal to the slope and the intercept on the y axis of the regression equation and Kow is octanol-water partition coefficient of each component under consideration.

GLP compliance:

no

Remarks:

not applicable (calculated by QSAR )

Test material

Reference

Name:

Unnamed

Type:

Constituent

Type:

Constituent

Sampling and analysis

Analytical monitoring:

not required

Test organisms

Test organisms (species):

other: not applicable (calculated by QSAR)

Study design

Test type:

other: not applicable (calculated by QSAR)

Water media type:

not specified

Remarks on exposure duration:

not applicable (calculated by QSAR)

Results and discussion

Effect concentrations

Effect concentrations 1

Dose descriptor:

EL50

Effect conc.:

1.4 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: not applicable (calculated by QSAR )

Effect concentrations 2

Dose descriptor:

NOELR

Effect conc.:

0.12 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: not applicable (calculated by QSAR )

Any other information on results incl. tables

Sublethal observations / clinical signs:

see attached full study report at "5.2.1 Biodegradation in water: screening tests" [ Attachment 8, page 5 -12]

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Remarks:

calculated by QSAR

Conclusions:

Results calculated by QSAR [using the methods described in the report by Peter Fisk Associates (2006)]:
- the substance could be acutely toxic to fish at a loading rate of 1.4 mg/l (EL50)
- the substance has a predicted chronic NOEL of 0.12 mg/l to fish.

Measurements in acute tests with related substances [reported in the environmental hazard property summary review by Peter Fisk Associates (2006) - see below 'Cross-reference to other study' or Attachment 8] show LC/LL50 values for fish in the range 10-30 mg/l (indicating a lower order of toxicity). It should be noted that the original study reports have not been reviewed.

Conclusion: Naphtha (Fischer-Tropsch), light, C4-10 - branched and linear, could be chronically toxic to fish at a loading rate of 0.1-1.0
mg/l and could be acutely toxic at a loading rate of 1-10 mg/l.

Classification: The substance should be classified in the EU as R50-53 i.e. 'Very toxic to aquatic organisms' and 'May cause long-term adverse effects in the aquatic environment'. The basis of this classification is the lowest predicted EL50 of 0,55 mg/l to algae and the presence of components with log Kow >3. The biodegradability does not affect this.