2-Butene, 1,1,4,4-tetramethoxy-

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15.01. - 07.02.1991

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study conducted under GLP

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1991

Report date:

1991

Materials and methods

Principles of method if other than guideline:

During the preliminary test, the test substance appeared to be hydrolytically unstable in water; the concentration of the cis-isomer
decreased with approximately 50% and the concentration of the transisomer decreased with approximately 80% during 19 hours at room
temperature. According to the OECO and EEC guidelines, the test is not applicable to unstable substances. Therefore, the water solubility
testing as described in the protocol was not performed. An alternative test was performed to determine whether the test substance is miscible
with water in 11 different ratios " test substance/water (v/v) ", ranging between 100 and 0.01, respectively.

GLP compliance:

yes (incl. QA statement)

Type of method:

other: See method description

Test material

Test material information

Constituent 1

Reference substance name:

(2E)-1,1,4,4-tetramethoxybut-2-ene; (2Z)-1,1,4,4-tetramethoxybut-2-ene

EC Number:

900-110-7

Cas Number:

5370-08-1

Molecular formula:

C8H16O4

IUPAC Name:

(2E)-1,1,4,4-tetramethoxybut-2-ene; (2Z)-1,1,4,4-tetramethoxybut-2-ene

Details on test material:

- Name of test material (as cited in study report): C4-Diacetale
- Physical state: colourless liquid
- Analytical purity: 97,1%
- Storage condition of test material: In a tightly closed container at room temperature in the dark

Results and discussion

Water solubility

Water solubility:

>= 250 vol%

Temp.:

18 °C

pH:

7

Any other information on results incl. tables

During the alternative test , the mixtures with the ratios (v/v) "l00", "50", "0.l ", "0.02" and "0.01" were clear colourless liquids in which no phase separation could be observed. At the beginning of the test , the mixture with the ratio (v/v) "0.2" showed phase-separation. However, after being shaken vigorously for the second time, the mixture with the ratio (v/v) ''0.2" became one clear, colourless phase. The mixtures with the ratios (v/v) "10", "5", "2", "1" and "0.5" showed phase separation at all observation periods of the test. Both phases were clear and colourless.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): miscible
In conclusion, C4-DIACETAL was determined to miscible with water at the ratios "test substance/Milli-Q water (v/v)" 250 and < 0.2 at ambient
temperature (approximately 18°C).

Executive summary:

During a preliminary test, C4 -DIACETAL appeared to be hydrolytically unstable in water. After incubation for 19 hours at room temperature, the concentration o f the cis-isomer decreased approximately 50% and the concentration of the trans-isomer decreased approximately 80%. Therefore, an alternative test was performed to determine visually the miscibility of the test substance with water, at different ratios "test substancelwater (v/v)" ranging between 100 and 0.01. During the alternative test, C4 -DIACETAL was determined to miscible with water at the ratios "test substance/water (v/v) 250 and 0.2.