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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1984-07-03 to 1984-07-30
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
2-Perfluoralkylethanol
IUPAC Name:
2-Perfluoralkylethanol

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: starch slime 2%
Doses:
5000 mg/kg bw and 4000 mg/gkbw
No. of animals per sex per dose:
5/sex/dose
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
at 4000 mg/kg bw disolved in starch slime 2%: 1/5 males and 0/5 females
at 5000 mg/kg bw disolved in starchslime 2 %: 2/5 males and 1/5 females
Clinical signs:
other: 5000 mg/kg bw dose: During the first days of observation males and females demonstrated hunched posture, staggered gate and ruffled fur. Males were free of any signs 4 days after treatment and females were free of any signes 6 days after treatment. 4000 m

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under the conditions of this test the LD50 oral rat of the test substance is considered to be about 5000mg/kg bw. Based on the test results the substance has not to be classified.
Executive summary:

The test substance was tested in an OECD 401 test for acute oral toxicity. Five rats/sex/dose were tested with 4000 and 5000mg/kg bw of the test substance disolved in strach slime 2%. 2/5 male and 1/5 females died within the 5000 mg/kg bw group. Within the 4000 mg/kg bw dose 1/5 males an 0/5 females died. Under the conditions of this test the LD50 oral rat of the test substance is considered to be about 5000mg/kg bw. Based on the test results the substance has not to be classified.