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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study predates GLP, but is similar to OECD TG 401.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972
Report date:
1972

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methyl-6-methyleneoct-7-en-2-ol
EC Number:
208-843-8
EC Name:
2-methyl-6-methyleneoct-7-en-2-ol
Cas Number:
543-39-5
Molecular formula:
C10H18O
IUPAC Name:
2-methyl-6-methylideneoct-7-en-2-ol
Test material form:
other: clear liquid
Details on test material:
Compound no. 70-39
Recieved 4/11/72

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals or test system and environmental conditions:
The body weight ranged from 200 to 250 grams.

Administration / exposure

Route of administration:
oral: unspecified
Details on oral exposure:
The drug was admistrered as a concentrate.
Doses:
4.0, 5.0, 6.25, and 7.8 g/kg bw
No. of animals per sex per dose:
10/dose, male
Control animals:
no
Details on study design:
-Rats were fasted for a minimum of 16 hours prior to adminstration of the test material.
-Observations for mortality were made at 1 and 6 hours after dosing and daily thereafter for fourteen days.
-Gross necropsies were performed on all survivors.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
5.3 mg/kg bw
Based on:
test mat.
95% CL:
>= 4.5 - <= 6.1
Mortality:
Death occurred overnight following administration of the drug.
2 animal died in the group dosed with 4.0 g/kg bw; 4 animals died in the group dosed with 4.0 g/kg bw; 7 animals died in the group dosed with 6.25 g/kg bw and 10 animals died in the group dosed with 7.8 g/kg bw.
Clinical signs:
other: The rats experienced ataxia, loss of righting reflex, lethargy, and piloerection. The

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
A LD50 of 5.3 mg/kg bw (95% CI = 4.5-6.1) was obtained in the acute oral toxicity study with rats.
Executive summary:

In an acute oral toxicity study with rats, similar to OECD TG 401 but without GLP, the LD50 was 5.3 mg/kg bw (95% CI - 4.5 - 6.1). Groups of 10 male albino rats, Wistar strain (age unspecified) were dosed with 4.0, 5.0, 6.25 and 7.8 g/kg bw and observed for 14 days. The numbers of animals that died were 2 at 4.0 g/kg bw, 4 at 5.0 g/kg bw, 7 at 6.25 g/kg bw, and 10 at 7.8 g/kg bw. Clinical findings included ataxia, piloerection, lethargy, and loss of righting reflex. Although Gross necropsies were performed on all suvivors findings were not reported.