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EC number: 203-527-6 | CAS number: 107-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- In principle, the methods described in OECD Guideline 401 were used.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- 3-methyl-2-butenal
- EC Number:
- 203-527-6
- EC Name:
- 3-methyl-2-butenal
- Cas Number:
- 107-86-8
- Molecular formula:
- C5H8O
- IUPAC Name:
- 3-methyl-2-butenal
- Details on test material:
- - Name of test material (as cited in study report): 3-Methyl-2-butenal
- Analytical purity: ca. 98%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: WIGA
- Weight at study initiation: mean group body weight range: males 190-260 g; females 160-190 g
- Fasting period before study: 15-20 hrs
- Diet: Herilan MRH-Haltung; Eggersmann KG
- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 3.16; 4.64; 5.62; 6.81; 8.25; 10.00 %
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg - Doses:
- 316, 464, 562, 681, 825, 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: 0, 15, 30 min, 1, 2, 4, 5 hours, day 1, daily thereafter on working days
- Frequency of weighing: day 0, 4 (except 562 mg/kg dosing group: weighing on day 3), 7, 13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology - Statistics:
- Model of Dose-Response-Relationship: F (P) = A+B* LN (D) with: D=dose; P=frequency of occurrence of death animals upon treatment with D; F= inverse function of the cumulative standardised normal distribution; LN=natural logarithm ; A+B= parameters of the model;
Test on homogeneity: chi-square test
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 690 mg/kg bw
- Mortality:
- Deaths occurred within 1 hr at 1000 mg/kg bw and 681 mg/kg bw or within 1 d after doses of 562, 681, 825 mg/kg bw. Mortalities were as follows: 0/10 animals at 316 or 464 mg/kg bw; 2/10 animals at 562 mg/kg bw; 3/10 animals at 681 mg/kg bw; 9/10 animals at 825 mg/kg bw; 10/10 animals at 1000 mg/kg bw.
- Clinical signs:
- other: dyspnoea; gasping; apathia; abnormal lateral position; staggering; tremor; muscle-twitching; spastic movement; saltation convulsions; trismus; tonic convulsions; scrubby coat; erythema; cyanosis; salivation; lacrimation; disturbance of equilibrium; poor g
- Gross pathology:
- deceased animals: heart: acute dilatation (both organ sites), acute congestive hyperemia; liver: peripheral injections of liver lobes (peripheral lobular pattern); stomach: proventriculus reddened; gastroesophageal vestibule:enhanced intravascular injection;
sacrificed animals: Stomach: esophageal vestibule wall thickened; development of gnathions; local adhesions of esophageal vestibule with liver, peritoneum and spleen
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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