Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Justification for classification or non-classification

BASF (1991) reported a guinea pig maximization test, done with EU method B.6. Female guinea pigs were given the test substance intradermal and epicutaneous in concentrations of 0.2% intradermal, 10% epicutan (induction) and 5% (challenge). One animal of the test group was found dead on day 8 after application.

Skin effects: - Well-defined erythema and slight edema were seen at the injection sites in both test and control animals. - Well-defined erythema and slight edema were also seen at the injection sites of the test substance in FCA/asline in test animals. - Well defined erythema, slight edema and incrustation were noted after percutaneous induction in the test animals. - Positive skin reactions, i.e. erythema, were observed in 3/9 test animals after the challenge procedure at both readings. No reactions (0/5 animals) were seen in the control group. The positive control substance led to positive skin reations (erythema) in 10/10 animals at both readings after the challenge.

Classification proposal for skin sensitizing according to Annex I of the EU Directive 67/548/EEC with R 43.