Registration Dossier
Registration Dossier
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EC number: 248-576-4 | CAS number: 27619-89-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Remarks:
- The study was conducted according to the guideline in effect at the time of study conduct.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2500 (Acute Dermal Irritation)
- Deviations:
- no
- Remarks:
- The study was conducted according to the guideline in effect at the time of study conduct.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride
- EC Number:
- 248-576-4
- EC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride
- Cas Number:
- 27619-89-2
- Molecular formula:
- C8H4ClF13O2S
- IUPAC Name:
- 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctane-1-sulfonyl chloride
- Details on test material:
- -Purity: > 98.0%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Immediately following patch removal and 30-60 minutes and 24, 48, and 72 hours after patch removal
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: range
- Time point:
- other: 1 hour to 72 hours
- Score:
- 0 - 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- edema score
- Basis:
- other: range
- Time point:
- other: 1 hour to 72 hours
- Score:
- 0 - 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 hours
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- Very slight to well-defined erythema (score of 1 or 2) and very slight edema (score of 1) was observed.
- Executive summary:
Five-tenths of a gram of the test substance was moistened with distilled water and then applied to the skin of three healthy rabbits for 4-hours. The dose site was evaluated for dermal irritation by the method of Draize et al. immediately following patch removal, and at 30-60 minutes and 24, 48, and 72 hours after patch removal.
Very slight to well-defined erythema (score of 1 or 2) was noted for all three treated dose sites and very slight edema (score of 1) was evident at one site. All animals were free from dermal irritation by 72 hours.
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