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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
Remarks:
The study was conducted according to the guideline in effect at the time of study conduct.
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.2500 (Acute Dermal Irritation)
Deviations:
no
Remarks:
The study was conducted according to the guideline in effect at the time of study conduct.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride
EC Number:
248-576-4
EC Name:
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride
Cas Number:
27619-89-2
Molecular formula:
C8H4ClF13O2S
IUPAC Name:
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctane-1-sulfonyl chloride
Details on test material:
-Purity: > 98.0%

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
no
Duration of treatment / exposure:
4 hours
Observation period:
Immediately following patch removal and 30-60 minutes and 24, 48, and 72 hours after patch removal
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
other: range
Time point:
other: 1 hour to 72 hours
Score:
0 - 2
Max. score:
4
Reversibility:
fully reversible within: 72 hours
Irritation parameter:
edema score
Basis:
other: range
Time point:
other: 1 hour to 72 hours
Score:
0 - 1
Max. score:
4
Reversibility:
fully reversible within: 72 hours

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Migrated information
Conclusions:
Very slight to well-defined erythema (score of 1 or 2) and very slight edema (score of 1) was observed.
Executive summary:

Five-tenths of a gram of the test substance was moistened with distilled water and then applied to the skin of three healthy rabbits for 4-hours. The dose site was evaluated for dermal irritation by the method of Draize et al. immediately following patch removal, and at 30-60 minutes and 24, 48, and 72 hours after patch removal.

Very slight to well-defined erythema (score of 1 or 2) was noted for all three treated dose sites and very slight edema (score of 1) was evident at one site. All animals were free from dermal irritation by 72 hours.