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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1977
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Qualifier:
equivalent or similar to guideline
Guideline:
other: MITI (guideline Nr. not specified)
GLP compliance:
no
Specific details on test material used for the study:
None
Radiolabelling:
not specified
Details on sampling:
no data
Vehicle:
not specified
Details on preparation of test solutions, spiked fish food or sediment:
no data
Test organisms (species):
Cyprinus carpio
Details on test organisms:
TEST ORGANISM
- Common name: common carp
Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
not specified
Remarks:
freshwater
Total exposure / uptake duration:
8 wk
Hardness:
no data
Test temperature:
no data
pH:
no data
Dissolved oxygen:
no data
TOC:
no data
Salinity:
no data
Details on test conditions:
no data
Nominal and measured concentrations:
Nominal: 0, 0.01 and 0.001 ppm = 1 and 10 µg/L
Reference substance (positive control):
no
Conc. / dose:
0.001 other: ppm
Type:
BCF
Value:
< 2 143 L/kg
Remarks on result:
other: Conc.in environment / dose:1 ppb
Conc. / dose:
0.01 other: ppm
Type:
other: AF
Value:
< 214 L/kg
Remarks on result:
other: Conc.in environment / dose:10 ppb
Details on kinetic parameters:
no data
Metabolites:
no data
Results with reference substance (positive control):
no data
Details on results:
no data
Reported statistics:
no data

Table 1: Results at 1 µg/L exposure concentration
Time Concentration in water (µg/L) Concentration in fish (µg/kg) BCF*
Week 1 < 36 < 2143 < 2143
Week 2 < 36 < 2143 < 2143
Week 3 < 36 < 2143 < 2143
Week 4 < 36 < 2143 < 2143
Week 5 < 36 < 2143 < 2143
Week 6 < 36 < 2143 < 2143
Week 7 < 36 < 2143 < 2143
Week 8 < 36 < 2143 < 2143
* Calculated using the nominal concentration of 1 µg/L
Table 2: Results at 10 µg/L exposure concentration
Time Concentration in water (µg/L) Concentration in fish (µg/kg) BCF*
Week 1 < 36 < 2143 < 214
Week 2 < 36 < 2143 < 214
Week 3 < 36 < 2143 < 214
Week 4 < 36 < 2143 < 214
Week 5 < 36 < 2143 < 214
Week 6 < 36 < 2143 < 214
Week 7 < 36 < 2143 < 214
Week 8 < 36 < 2143 < 214
* Calculated using the nominal concentration of 10 µg/L
Validity criteria fulfilled:
no
Conclusions:
Under the conditions of a MITI test, the bioconcentration factor (= concentration in fish / concentration in water) in carp at 1 µg/L was <2143 L/kg. At 10 µg/L, it was <214 L/kg. These results suggest that the test substance has a low bioconcentration potential in fish.
Executive summary:

A study was conducted to assess the bioconcentration potential of the test substance (of ca. 89 % purity) in common carp (Cyprinus carpio) according to the MITI method.

Fish were exposed at 1 and 10 ppb (= 1 and 10 µg/L) for 8 weeks. Average concentrations in water and fish were recorded weekly. At 1 µg/L, the bioconcentration factor (= concentration in fish / concentration in water) was <2143 L/kg. At 10 µg/L, it was <214 L/kg. These results suggest that the test substance has a low bioconcentration potential in fish.

Description of key information

A study was conducted to assess the bioconcentration potential of the test substance (of ca. 89 % purity) in common carp (Cyprinus carpio) according to the MITI method.

Fish were exposed at 1 and 10 ppb (= 1 and 10 µg/L) for 8 weeks. Average concentrations in water and fish were recorded weekly. At 1 µg/L, the bioconcentration factor (= concentration in fish / concentration in water) was <2143 L/kg. At 10 µg/L, it was <214 L/kg. These results suggest that the test substance has a low bioconcentration potential in fish.

Key value for chemical safety assessment

BCF (aquatic species):
214 L/kg ww

Additional information