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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The original study is classified as reliable with restriction because although the study was not GLP compliant, it was conducted according to FHSLA recommendations. For the purposes of this use it is rated as reliable with restrictions since it is being used for read across purposes.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Federal Hazardous Substances Labeling Act
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Hexadec-1-ene
EC Number:
211-105-8
EC Name:
Hexadec-1-ene
Cas Number:
629-73-2
IUPAC Name:
hexadec-1-ene

Test animals / tissue source

Species:
rabbit
Strain:
other: albino

Test system

Vehicle:
not specified
Controls:
other: The non-treated eye of each animal was used as a control. A positive control substance was also tested.
Amount / concentration applied:
0.01 ml of the test material was instilled into one eye of six male rabbits.
Details on study design:
SCORING SYSTEM: The Draize scoring system was used.

Results and discussion

In vivo

Results
Irritation parameter:
other: Draize
Basis:
mean
Time point:
other: 24 hour
Score:
0.7
Remarks on result:
other: Not irritating
Irritant / corrosive response data:
Instillation of 1-hexadecene in the eyes produced mild, transient redness of the conjunctival tissue. No effects on the cornea or iris were observed. Based on this test result, the author concluded that 1-hexadecene is not an eye irritant to albino rabbits.
Other effects:
The eye treated with control substance, 5% Ivory solution, showed greater response than any of the test substances.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Instillation of 1-hexadecene in the eyes produced mild, transient redness of the conjunctival tissue. No effects on the cornea or iris were observed. Based on this test result, the author concluded that 1-hexadecene is not an eye irritant to albino rabbits.
Executive summary:

In a primary eye irritation study, 0.1 millilitre of 1-hexadecene was instilled into the conjunctival sac of six male albino rabbits. Treated eyes were not washed during exposure. The animals were observed at 24, 48 and 72 hours after exposure. Irritation was scored by the Draize method. In this study, 1-hexadecene is not an eye irritant based on the 24 hour average redness Draize score of 0.7. This result for the substance hexadec-1 -ene can be considered representative of the likely result that would be seen with the isomer 7 -methylenepentadecane.

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