Registration Dossier
Registration Dossier
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EC number: 258-038-0 | CAS number: 52605-52-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Henry F. Smyth Jr., Charles P. Carpenter, Carrol S. Well, Urbano C. Pozzani & Jean A. Striegel
- Year:
- 1 962
- Bibliographic source:
- American Industrial Hygiene Association Journal, 1962, 23:2, 95-107
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Primary dermal irritation study was carried out on rabbits to assess the irritation potential of the test chemical
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-piperazin-1-ylethylamine
- EC Number:
- 205-411-0
- EC Name:
- 2-piperazin-1-ylethylamine
- Cas Number:
- 140-31-8
- Molecular formula:
- C6H15N3
- IUPAC Name:
- 1-(2-Aminoethyl) piperazine
- Test material form:
- liquid
- Details on test material:
- Name of the test chemical: 1-(2-Aminoethyl) piperazine
Molecular Formula:C6H15N3
Molecular Weight: 129.206 g/mol
InChI: 1S/C6H15N3/c7-1-4-9-5-2-8-3-6-9/h8H,1-7H2
Substance Type: Organic
Physical State: Liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: closely clipped, intact abdominal skin
- Amount / concentration applied:
- 0.01 ml of undiluted sample or of solutions in water, acetone, propylene glycol
- Duration of treatment / exposure:
- 24 hours
- Number of animals:
- 5
- Details on study design:
- TEST SITE
Area of exposure: closely clipped, intact abdominal skin
% coverage: No data
Type of wrap if used: no wrap used
REMOVAL OF TEST SUBSTANCE
Washing (if done): no data
Time after start of exposure: no data
SCORING SYSTEM:
Primary skin irritation on rabbits was recorded in a 10-grade ordinal series. Grade 1 indicates no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 6
- Max. score:
- 10
- Reversibility:
- not specified
- Remarks on result:
- probability of moderate irritation
- Irritant / corrosive response data:
- Moderate irritation observed
Any other information on results incl. tables
Table: Results of the irritation study
Material tested |
Irritation on uncovered rabbit belly |
140 -31 -8 |
6 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- Acute dermal irritation study was carried out to assess the irritation potential of the test chemical.
Primary Irritation score after 24 hours for the test chemical was Grade 6.
Based on this grade,the test chemical can be considered moderately irritating to rabbit skin. - Executive summary:
Acute dermal irritation study was carried out to assess the irritation potential of the test chemical.
Primary skin irritation on rabbits was recorded in a 10-grade ordinal series and was based upon the severest reaction that develops on the clipped abdominal skin of each of five albino rabbits within 24 hours of the uncovered application of 0.01 ml of undiluted sample or of solutions in water, propylene glycol, or acetone.
Grade 1 indicates no irritation and Grade 2 the least visible capillary injection from the undiluted chemical. Grade 6 indicates necrosis when undiluted and Grade 10 indicates necrosis from a 0.01% solution
Primary Irritation score after 24 hours for the test chemical was Grade 6.
Based on this grade,the test chemical can be considered moderately irritating to rabbit skin.
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