Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-816-1 | CAS number: 88-27-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
- Genetic toxicity in vitro: Bacterial reverse mutation assay:
1.- Key study: Read-across from experimental data on the analogue CAS No. 103-83-3. Equivalent to OECD 471 and 472.
The test substance was not mutagenic to Salmonella typhimurium TA100, TA1535, TA98, TA1537 and Escherichia coli WP2 uvrA, with or without an exogeneous metabolic activation system.
2.- Key study: Read-across from experimental data on the analogue CAS No. 1477-55-0. Equivalent to OECD 471 and 472.
The substance is not mutagenic with or without metabolic activation under the conditions of the test.
3.- Weight of evidence: Experimental results from scientific articles and reviews. Read-across from experimental data on the analogue CAS No.128-37-0.
The substance is not mutagenic.
- Genetic toxicity in vitro: Mammalian chromosome aberration assay:
1.- Key study: Read-across from experimental data on the analogue CAS No. 103-83-3. Equivalent to OECD 473.
The test substance induced structural chromosomal aberrations with an exogeneous metabolic activation system.
2.- Key study: Read-across from experimental data on the analogue CAS No. 1477-55-0. Equivalent to OECD 473.
The chemical was not clastogenic under the conditions of the assay.
3.- Weight of evidence: Experimental results from scientific articles and reviews. Read-across from experimental data on the analogue CAS No.128-37-0.
The substance did not cause chromosomal aberrations in mammalian cells in vitro.
- Genetic toxicity in vitro: Mammalian cell gene mutation assay:
1.- Key study: Read-across from experimental data on the analogue CAS No. 1477-55-0. Equivalent to OECD 476.
The test material did not induce any toxicologically significant increases in the mutant frequency at the TK +/- locus in L5178Y cells and is therefore considered to be non mutagenic under the conditions of the test.
2.- Weight of evidence: Experimental results from scientific articles and reviews. Read-across from experimental data on the analogue CAS No.128-37-0.
The substance did not cause point mutations in mammalian cells in vitro.
- Genetic toxicity in vivo: Chromosome aberration test:
1.- Key study: Read-across from experimental data on the analogue CAS No. 103-83-3. Equivalent to OECD guideline 474.
The test substance did not show any mutagenic activity as determined by the micronucleus test with mouse bone marrow cells.
2.- Weight of evidence: Experimental results from scientific articles and reviews. Read-across from experimental data on the analogue CAS No.128-37-0.
The substance is considered as negative for the genetic toxicity in vivo.
Justification for selection of genetic toxicity endpoint
No study was selected, since the results obtained in the in vitro studies (Ames test and Mammalian cell gene mutation assay) and the results obtained in the in vivo studies (Chromosome aberrations tests) were negative.
Short description of key information:
Bacterial reverse mutation assay (in vitro):
1.Key study: Read-across from experimental data on the analogue CAS No. 103-83-3. Equivalent to OECD 471 and 472.
The test substance was not mutagenic.
2.Key study: Read-across from experimental data on the analogue CAS No. 1477-55-0. Equivalent to OECD 471 and 472.
The substance is not mutagenic.
3.Weight of evidence: Experimental results from scientific articles and reviews. Read-across from experimental data on the analogue CAS No.128-37-0.
The substance is not mutagenic.
Mammalian chromosome aberration assay (in vitro):
1.Key study: Read-across from experimental data on the analogue CAS No. 103-83-3. Equivalent to OECD 473.
The test substance induced structural chromosomal aberrations with an exogeneous metabolic activation system.
2.Key study: Read-across from experimental data on the analogue CAS No. 1477-55-0. Equivalent to OECD 473.
The substance was not clastogenic under the conditions of the assay.
3.Weight of evidence: Experimental results from scientific articles and reviews. Read-across from experimental data on the analogue CAS No.128-37-0.
The substance did not cause chromosomal aberrations.
Mammalian cell gene mutation assay (in vitro):
1.Key study: Read-across from experimental data on the analogue CAS No. 1477-55-0. Equivalent to OECD 476.
The test material is considered to be non mutagenic.
2.Weight of evidence: Experimental results from scientific articles and reviews. Read-across from experimental data on the analogue CAS No.128-37-0.
The substance did not cause point mutations.
Chromosome aberration test (in vivo):
1.Key study: Read-across from experimental data on the analogue CAS No. 103-83-3. Equivalent to OECD guideline 474.
The test substance did not show any mutagenic activity.
2.Weight of evidence: Experimental results from scientific articles and reviews. Read-across from experimental data on the analogue CAS No.128-37-0.
The substance is considered as negative.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available data, the substance is not classified for genetic toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
