Registration Dossier

Toxicological information

Repeated dose toxicity: oral

Currently viewing:

Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only very little information is available. The information is based on an internal memorandum with a short summary of the results of a study report. The full study report is not available.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1981

Materials and methods

GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(RS)-2-[4-(5-Trifluoromethyl-2-pyridyloxy)phenoxy]propionic
EC Number:
614-949-9
Cas Number:
69335-91-7
Molecular formula:
C15H12F3NO4
IUPAC Name:
(RS)-2-[4-(5-Trifluoromethyl-2-pyridyloxy)phenoxy]propionic
Constituent 2
Reference substance name:
2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid
IUPAC Name:
2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid
Details on test material:
The test substance is the racemate 2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 69335-91-7). It is a 1:1 mixture of the two enantiomers (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 83066-88-0; the substance defined in section 1) and (2S)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 95977-30-3).

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
30 days
Frequency of treatment:
not applicable (repeated dietary administration)
Doses / concentrationsopen allclose all
Dose / conc.:
50 ppm
Remarks:
Basis:
no data
Dose / conc.:
500 ppm
Remarks:
Basis:
no data
No. of animals per sex per dose:
no data

Results and discussion

Results of examinations

Details on results:
Repeated dietary administration for 30 days to rats produced significant liver enlargement in male rats fed 50 ppm or 500 ppm and slight liver damage (cloudy swelling and or hypertropy of hepatocytes) at 500 ppm. No effects were seen in female rats at these doses. All feed concentrations refer top the test substance (i.e. the racemate).

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Full information as given in the memorandum:

Repeated dietary administration for 30 days to rats produced significant liver enlargement in male rats fed 50 ppm or 500 ppm and slight liver damage (cloudy swelling and or hypertrophy of hepatocytes) at 500 ppm. No effects were seen in female rats at these doses.

Applicant's summary and conclusion