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EC number: 939-685-4 | CAS number: 1474044-71-7
Endpoint summary
Administrative data
Description of key information
Additional information
The biodegradation of MDIPA Esterquat C18 unsatd. (98.8% a.i.) was investigated in a study conducted according to OECD Guideline 301 F, adopted 17th July 1992 (Ready Biodegradability: Manometric Respirometry Test) and EU Method C.4-D, 2008, over a period of 28 days using activated sludge sampled from a sewage treatment plant mainly fed with municipal wastewater as inoculum. The biodegradation rate was determined by measurement of O2 consumption. Inoculum blank, toxicity control and procedural/functional control with the reference substance Sodium benzoate were performed. The test was performed with 24 and 100 mg/L test substance concentration.The functional control reached the pass level >60% after 14 d (91%).
With 0%, nitrification of test item originated nitrogen can be neglected. Therefore, mineralization of the test item was evaluated on the basis of ThOD NH3. The biodegradation of the test item after 28 days of incubation in the static test was found to be 60% (SD = 6.0 %) in the assays with 100 mg/L and 74% (SD = 0.0%) in the assays with 24 mg/L based on ThOD NH3. Biodegradation on the basis of ThODNH3 at the end of the 10-day-window was found to be 42% in the assays with 100 mg/L and 60% in the assays with 24 mg/L. The 10-day-window started on day 2 – 3, depending on the concentration. With 0%, there was no abiotic degradation of the test item noticeable within the 28 days of incubation. The biodegradation of the item mixture in the toxicity control was found to be 23% after 14 days of incubation. Thus, the demanded threshold value of 25% is undercut. Nevertheless, due to comparable absolute oxygen demand to the reference assays, and test assays surpassing the threshold value of 60% degradation within a 10-day-window, the test item can be identified as being non-toxic in a ready biodegradability test.
In this test, MDIPA Esterquat C18 unsatd. was readily biodegradable.
In a further test according to OECD Guideline 301 F, adopted 17th July 1992 (Ready Biodegradability: Manometric Respirometry Test) and EU method C.4 -D (1992), MDIPA Esterquat C18 unsatd. was also found to be readily biodegradable and not inhibitory towards microorganisms.
Due to a high COD of 2.29 mg O2/mg test item in this further test, the test item suspension with a concentration of 50 mg/L met the criteria of 50 - 100 mg ThOD or COD/L, as demanded in the guideline. At a concentration of 50 mg/L, the test item obtained a biodegradation above 60% within the test duration.Although the 10 day window criterion was not fulfilled in this test, the test substance can be regarded as readily biodegradable according to the Guidance on information requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance “These pass levels have to be reached in a 10-day window within the 28-day period of the test. The 10-day window does not apply to TG 301 C or if the test substance represents a mixture of homologous compounds e.g. technical surfactants.”
Similar results were obtained with the closely related read-across substance MDEA-EsterquatC16-18 and C18 unsatd.:
The biodegradation of MDEA-EsterquatC16-18 and C18 unsatd. was studied in accordance with the OECD TG 301 B, and in compliance with GLP standards for 28 d. MDEA-EsterquatC16-18 and C18 unsatd. was applied at 2 concentration of 10 and 20 mg/l. CO2 production was analysed at 0, 1, 4, 5, 7, 8, 11, 14, 18, 22, and 28 days of incubation.The two test treatments (10 and 20 mg/L) reached > 60% CO2 production and met the 10 -day window. Therefore MDEA-Esterquat C16-18 and C18 unsatd. fulfills the OECD criteria of ready biodegradability.
According to Annex IX 9.2.1.2. and 9.2.1.4 Column 2, a study on biodegradation in water and sediment does not need to be conducted as the substance is readily biodegradable (experimental result please see chapter 5.2.1).
According to Annex IX 9.2.1.3. Column 2, a study on biodegradation in soil does not need to be conducted as the substance is readily biodegradable (experimental result please see chapter 5.2.1.).
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