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Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

N-[2-(piperazin-1-yl)ethyl]C18-unsaturated-alkylamide is quickly degraded and N-(2-aminoethyl)piperazine (CAS no 140 -31 -8) is formed as metabolite. This is in perfect agreement with the available biodegradability results for N-(2 -aminoethyl)piperazine. In an STP simulation study >99.99% removal of N-[2-(piperazin-1-yl)ethyl]C18-unsaturated-alkylamide was observed from which 0.042% via adsorption to sludge using specific chemical analyses based on high recoveries of spiked sludge and effluent samples.

Based on the 89 +/-1% (95% confidence interval) DOC removal observed in the simulation study, a large fraction of N-(2-aminoethyl)piperazine has have been removed via sorption when taking the Henry's law constant (9.3 * 10^-9 Atm/m3/mol) and Koc of 37000 L/kg of N-(2-aminoethyl)piperazine into account.

Additional information

Based on the available biodegradation results partial biodegradation of N-[2 -(piperazin-1 -yl)ethyl]C18 -insaturated-alkylamide is demonstrated where N-(2-aminoethyl)piperazine  (CAS Num: 140 -31 -8) has been identified as the product formed (Geerts et al.,2014). This means that the parent; N-[2 -(piperazin-1 -yl)ethyl]C18 -insaturated-alkylamide is most likely completely removed within 28 days in the ready test.

Based on the uses claimed for N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide soil exposure is likely. It is however very unlikely that further degradation of N-(2-aminoethyl)piperazine will occur in soil. Further testing in soil is therefore not expected to deliver more information. For soil therefore a worst-case half life value of 3000 days (Kd = 2000 L/kg) is used. In accordance with column 2 of REACH annex IX, further degradation testing does not need to be conducted as the chemical safety assessment does not indicate a need for further investigation. Based on the available biodegradation results partial biodegradation of N-[2 -(piperazin-1 -yl)ethyl]C18 -insaturated-alkylamide is demonstrated where N-(2-aminoethyl)piperazine  (CAS Num: 140 -31 -8) has been identified as the product formed. This means that the parent; N-[2 -(piperazin-1 -yl)ethyl]C18 -insaturated-alkylamide is most likely completely removed within 28 days in the ready test. Based on the uses claimed for N-[2-(piperazin-1-yl)ethyl]C18-insaturated-alkylamide soil exposure is likely. It is however very unlikely that further degradation of N-(2-aminoethyl)piperazine will occur in soil. Further testing in soil is therefore not expected to deliver more information. For soil therefore a worst-case half life value of 3000 days (Kd = 2000 L/kg) is used. In accordance with column 2 of REACH annex IX, further degradation testing does not need to be conducted as the chemical safety assessment does not indicate a need for further investigation.