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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

The worst-case representative and main constituent of N-[2-(piperazin-1-yl)ethyl]C18-unsatured-alkylamide (AA-AEP, CAS No 1228186-18-2) was shown to be rapidly biodegadable in an OECD 309 test with a very short half-life of 4.1/4.8 days at test concentration of 10/100 µg/L (at 12 °C) and long-term exposure of aquatic organisms is therefore not expected. The mineralisation of the AA-AEP is however not complete as (Piperazin-1-yl)acetic acid (CAS no.: 37478-58-3) is remaining after 90 days of testing at 12°C.


This metabolite, (Piperazin-1-yl)acetic acid, is based on the available data considered to be persistent but has a low bioaccumulation potential based on the low calculated log Kow of -3.36 and a very high water solubility of 1000 g/L and the available bioaccumulation data on the structural analogue piperazine (CAS 110-85-0): The BCF of piperazine was determined in the carp (Cyprinus carpio), where the measured BCF was < 3.9 L/kg at 0.1 mg/L exposure (CERI, 2004).

Additional information

The bioaccumulation potential of AA-AEP was not evaluated using the log Kow as the substance is a polar narcotic and there is only limited information on the relationship between log Kow and BCF for this type of substances. Performance of a standard OECD 305 test is however scientifically and ethically not considered appropriate for AA-AEP because there will be no long-term exposure and the substance will therefore not accumulate in the food-chain. The substance is either sorbed or degraded. The OECD 309 study showed however, that the mineralisation of AA-AEP is not complete as a significant fraction of (Piperazin-1-yl)acetic acid (CAS no.: 37478-58-3) was observed to be remaining after 90 days of testing at 12°C.


 


This metabolite (Piperazin-1-yl)acetic acid is based on the available data considered persistent but has a low bioaccumulation potential based on the low calculated log Kow of -3.36 and a very high water solubility of 1000 g/L and the available bioaccumulation data on the structural analogue piperazine (CAS 110-85-0): The BCF of piperazine was determined in the carp (Cyprinus carpio), where the measured BCF was < 3.9 L/kg at 0.1 mg/L exposure (CERI, 2004).


 


Reference: CERI(2004). Database of Biodegradation and Bio-Accumulation Data of existingchemicals. Chemicals Evaluation and Research Institute, Japan. Available at http://www.nite.go.jp/en/chem/qsar/cscl_data.html