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To address the bioaccumulation potential according to REACH requirements, the log Kow of N-[2-(piperazin-1-yl) ethyl] C18-insaturated-alkylamide was measured applying slow stirring method according to OECD 123. The observed log Kow value (Log Kow>3) indicates that the substance may have a bioaccumulation potential if N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide would have been a narcotic substance. For polar narcotics like the N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide however there is only limited information on the relationship between log Kow and BCF.

Based on the non-persistency of the parent product: N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide and the negligible emission to surface water, accumulation in the food chain is considered to be unlikely and further bioaccumulation testing of N-[2-(piperazin-1-yl) ethyl]C18-insaturated-alkylamide (CAS no 1228186-18-2) can be waived according to column 2 of REACH Annex IX.


The metabolite formed; N-(2-aminoethyl)piperazine (CAS no 140 -31 -8) is however considered to be persistent. N-(2-aminoethyl)piperazine has however a very low measured/calculated log Kow of -1.48/-1.57 and is based on its structure not expected to have a significant bioaccumulation potential. Bioaccumulation data on the structural analogue piperazine (CAS 110-85-0) support this conclusion: The BCF of piperazine was determined in the carp (Cyprinus carpio), where the measured BCF was < 3.9 L/kg at 0.1 mg/L exposure (CERI, 2004).

Despite of its low log Kow also N-(2-aminoethyl)piperazine is not considered to be mobile based on it high Koc of 37000 L/kg.

Bioaccumulation in terrestrial organisms is not a formal REACH requirement.