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EC number: 629-767-5 | CAS number: 1228186-18-2
Endpoint summary
Administrative data
Description of key information
The worst-case representative and main constituent of N-[2-(piperazin-1-yl)ethyl]C18-unsatured-alkylamide (AA-AEP, CAS No 1228186-18-2) was shown to be rapidly biodegadable in an OECD 309 test with a very short half-life of 4.1/4.8 days at test concentration of 10/100 µg/L (at 12 °C) and long-term exposure of aquatic organisms is therefore not expected. The mineralisation of the AA-AEP is however not complete as (Piperazin-1-yl)acetic acid (CAS no.: 37478-58-3) is remaining after 90 days of testing at 12°C.
This metabolite, (Piperazin-1-yl)acetic acid, is based on the available data considered to be persistent but has a low bioaccumulation potential based on the low calculated log Kow of -3.36 and a very high water solubility of 1000 g/L and the available bioaccumulation data on the structural analogue piperazine (CAS 110-85-0): The BCF of piperazine was determined in the carp (Cyprinus carpio), where the measured BCF was < 3.9 L/kg at 0.1 mg/L exposure (CERI, 2004).
Additional information
The bioaccumulation potential of AA-AEP was not evaluated using the log Kow as the substance is a polar narcotic and there is only limited information on the relationship between log Kow and BCF for this type of substances. Performance of a standard OECD 305 test is however scientifically and ethically not considered appropriate for AA-AEP because there will be no long-term exposure and the substance will therefore not accumulate in the food-chain. The substance is either sorbed or degraded. The OECD 309 study showed however, that the mineralisation of AA-AEP is not complete as a significant fraction of (Piperazin-1-yl)acetic acid (CAS no.: 37478-58-3) was observed to be remaining after 90 days of testing at 12°C.
This metabolite (Piperazin-1-yl)acetic acid is based on the available data considered persistent but has a low bioaccumulation potential based on the low calculated log Kow of -3.36 and a very high water solubility of 1000 g/L and the available bioaccumulation data on the structural analogue piperazine (CAS 110-85-0): The BCF of piperazine was determined in the carp (Cyprinus carpio), where the measured BCF was < 3.9 L/kg at 0.1 mg/L exposure (CERI, 2004).
Reference: CERI(2004). Database of Biodegradation and Bio-Accumulation Data of existingchemicals. Chemicals Evaluation and Research Institute, Japan. Available at http://www.nite.go.jp/en/chem/qsar/cscl_data.html
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